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UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3190
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3190
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Hampshire Instruments, Inc.
P. O. Box 10159 Rochester, NY 14610
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES IS IMPORTANT IN BOTH BASIC MEDICAL SCIENCE AND CLINICAL PATHOLOGY DIAGNOSIS.
Agency: HHS
Contract: N/A
Award Amount: $49,740.00
 

Abstract:

UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES IS IMPORTANT IN BOTH BASIC MEDICAL SCIENCE AND CLINICAL PATHOLOGY DIAGNOSIS. TO HELP ADDRESS THIS NEED, HAMPSHIRE INSTRUMENTS IS DEVELOPING A HIGH-RESOLUTION THREE-DIMENSIONAL OPTICAL MICROSCOPY WORKSTATION WITH SIGNIFICANT COMPUTATIONAL AND INTERACTIVE GRAPHICS CAPABILITY. THIS INSTRUMENT WILL INCORPORATE THREE-DIMENSIONAL DEBLURRING ALGORITHMS USED TO SHARPEN IMAGES FROM OPTICALLY SECTIONED THICK SPECIMENS, IN BOTH ABSORPTION AND FLUORESCENCE MICROSCOPY. DURING PHASE I, 1.A MICROCOMPUTER BASED HIGH-RESOLUTION OPTICAL MICROSCOPY DEVELOPMENT SYSTEM WILL BE CONSTRUCTED; 2.THREE-DIMENSIONAL DEBLURRING ALGORITHMS FOR FLUORESCENCE AND 3.THE EFFECT OF UNAVOIDABLE PARTIAL COHERENCE OF ILLUMINATION IN HIGH-RESOLUTION MICROSCOPY ON THE VALIDITY OF THREE-DIMENSIONAL DEBLURRING ALGORITHMS WILL BE DETERMINED;4.HUMAN CANCER NUCLEI CELLS WILL BE EXAMINED TO ASSESS THE USEFULNESS OF THREE-DIMENSIONAL DEBLURRING PROCEDURES ON NUCLEAR FEATURES THAT HAVE BEEN SHOWN TO BE OF PROGNOSTIC OR DIAGNOSTIC VALUE; AND 5. HARDWARE AND SOFTWARE SPECIFICATIONS FOR PHASE II CONSTRUCTION OF THE COMMERCIAL PROTOTYPE HIGH-RESOLUTION THREE-DIMENSIONAL OPTICAL MICROSCOPY WORKSTATION WILL BE DEVELOPED.

Principal Investigator:

Robert d. frankel
PRINCIPAL INVESTIGATOR
7164824070

Business Contact:

Small Business Information at Submission:

Hampshire Instruments, Inc.
P. O. Box 10159 Rochester, NY 14610

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No