USA flag logo/image

An Official Website of the United States Government

EXPRESSION OF DENGUE 3 ENVELOPE AND NONSTRUCTURAL 1 GLYCOPROTEINS IN THE FUNGUS…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
12551
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
12551
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: EXPRESSION OF DENGUE 3 ENVELOPE AND NONSTRUCTURAL 1 GLYCOPROTEINS IN THE FUNGUS NEUROSPORA CRASSA
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $67,723.00
 

Abstract:

THE FOUR SEROTYPES OF DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. FOR THE DEVELOPMENT OF DIAGNOSTICS FOR AND SUBUNIT VACCINES AGAINST DENGUE VIRUS, A RELIABLE AND INEXPENSIVE SOURCE OF DENGUE PROTEINS IS NEEDED. THE EXPRESSION OF RECOMBINANT PROTEINS IN MICROORGANISMS OFFER SIGNAITICANT ADVANTAGES TO PURIFICATION OF NATIVE VIRAL PROTEINS. WE PROPOSE TO EVALUATE THE USE OF THE FUNGUS NEUROSPORA CRASSA TO PRODUCE AUTHENTIC DENGUE 3 ENVELOPE AND NONSTRUCTURAL 1 GLYCOPROTEINS.THE SEQUENCES ENCODING THESE PROTEINS WILL BE PLACED UNDER THE TRANSCRIPTIONAL CONTROL OF A CONSTITUTUVE NEUROSPORA PROMOTER, EITHER WITH THEIR OWN SECRETION SIGNAL PEPTIDES OR WITH A HETEROLOGOUS SIGNAL PEPTIDE. THE PROTEIN PRODUCED WILL BE EVALUATED WITH RESPECT TO MOLECULAR WEIGHT, GLYCOSYLATION AND ANTIGENICITY.

Principal Investigator:

Dr John M Ivy
8084865333

Business Contact:

Small Business Information at Submission:

Hawaii Biotechnology Group Inc
99-193 Aiea Heights Dr Aiea, HI 96701

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No