PALYTOXIN PRODRUG ACTIVATION BY ANTIBODY-LINKED ENZYME

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 16417	Program Year/Program: 1992 / SBIR
Agency Tracking Number: 16417	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI 96701-3900
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Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 2: Fiscal Year: 1992

Title: PALYTOXIN PRODRUG ACTIVATION BY ANTIBODY-LINKED ENZYME

Agency: HHS

Contract: N/A

Award Amount: $459,212.00

Abstract:
PALYTOXIN IS AN EXTREMELY CYTOTOXIC LOW MOLECULAR WEIGHT NATURAL PRODUCT ISOLATED FROM SOFT CORALS OF THE GENUS, PALYTHOA. N-ACYLATED DERIVATIVES OF PALYTOXIN HAVE BEEN REPORTED TO BE UP TO 100-FOLD LESS CYTOTOXIC THAN THE UNMODIFIED TOXIN. PALYTOXIN N-ACYL DERIVATIVES WHICH CAN BE CONVERTED TO THE NATIVE TOXIN BY ANTITUMOR MONOCLONAL ANTIBODY- ENZYME CONJUGATES WILL BE PREPARED AND TESTED FOR ANTIGEN-SELECTIVE CYTOTOXICITY AGAINST CELLS IN CULTURE.

Principal Investigator:
Bignami, Gary S
Principal Investigator
8084865397

Business Contact:
1 r43 ca54652-01

Small Business Information at Submission:

Hawaii Biotechnology Group, In
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No