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COFFEE ALPHA-GALACTOSIDASE CDNA CLONING FOR BLOOD PROCESSING

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16691
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16691
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: COFFEE ALPHA-GALACTOSIDASE CDNA CLONING FOR BLOOD PROCESSING
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

IT HAS BEEN DEMONSTRATED THAT ALPHA-GALACTOSIDASE AND ALPHA-N-ACETYL GALACTOSAMINIDASE HAVE THE ABILITY TO ENZYMATICALLY CONVERT TYPE B AND A HUMAN ERYTHROCYTES, RESPECTIVELY, TO SEROTYPICALLY TYPE O ERYTHROCYTES. THIS ABILITY WOULD OBVIATE THE NEED FOR TYPING OR CROSSMATCHING, WOULD SIMPLIFY INVENTORY IN BLOOD BANKS, AND WOULD EXPEDITE THE DELIVERY OF TRANSFUSIONS. WE WILL SYNTHESIZE AND CLONE THE CDNA ENCODING THE ALPHA-GALACTOSIDASE FOUND IN GREEN COFFEE BEANS FOR EVENTUAL PRODUCTION IN MICROBIAL EXPRESSION SYSTEMS. DURING PHASE I, THIS WILL ENTAIL IDENTIFYING A COFFEE TISSUE TO USE AS A SOURCE OF THE ALPHA-GALACTOSIDASE MRNA, CDNA SYNTHESIS AND CLONING, AND IDENTIFYING RECOMBINANT CDNA CLONES EXPRESSING PROTEIN RECOGNIZED BY ANTI-ALPHA-GALACTOSIDASE ANTISERUM.

Principal Investigator:

Ivy, John M
Principal Investigator
8084865333

Business Contact:

1 r43 hl46043-01
Small Business Information at Submission:

Hawaii Biotechnology Group, In
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No