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IMMUNOASSAYS FOR BRYOSTATINS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
18989
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
18989
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1994
Title: IMMUNOASSAYS FOR BRYOSTATINS
Agency: HHS
Contract: N/A
Award Amount: $483,000.00
 

Abstract:

THE OVERALL GOALS OF THIS PROJECT ARE TO DEVELOP IMMUNOASSAYS FOR THE DETECTION OF BRYOSTATIN 1 AND ITS ANALOGUES IN A VARIETY OF BIOLOGICAL MATRICES. THE BRYOSTATINS HAVE EXHIBITED STRONG ANTINEOPLASTIC ACTIVITY IN PRECLINICAL STUDIES AND ARE SCHEDULED TO ENTER PHASE I CLINICAL TRIALS LATER THIS YEAR. SENSITIVE ANALYTICAL METHODS ARE NEEDED FOR ESTABLISHING THE PROPER DOSING REGIMENS IN THESE STUDIES AND FOR MAXIMIZING YIELDS DURING THE LARGE SCALE ISOLATION OF THESE SCARCE NATURAL PRODUCTS. IN ADDITION, THE AVAILABLIITY OF BRYOSTATIN IMMUNOASSAYS WOULD FACILITATE BASIC RESEARCH EFFORTS TO DETERMINE THE BIODYNTHESIS AND ACTUAL SOURCE OF THESE INTERESTING COMPOUNDS. WE PLAN TO SYNTHESIZE WILL CHARACTERIZED BRYOSTATIN IMMUNOGENS WHICH SHOULD ELICIT ANTIBODY RESPONSES IN RABBITS AND MICE. THE GOAL OF PHASE I RESEARCH WILL BE TO DEMONSTRATE THE FEASIBILITY OF PRODUCING BRYOSTATIN IMMUNOASSAYS UTILIZING POLYCLONAL RABBIT ANTIBODIES. PHASE II RESEARCH WILL FOCUS ON REFINING THESE ASSAYS, PRODUCTION OF ADDITIONAL MONOCLONAL ANTIBODY-BASED IMMUNOASSAYS OF VARYING SPECIFICITIES FOR PARTICULAR APPLICATIONS, AND DEVELOPING PROCEDURES FOR DETERMINING BRYOSTATIN CONCENTRATIONS IN VARIOUS BIOLOGICAL MATRICES.

Principal Investigator:

Paul G Grothaus
8084865333

Business Contact:

Small Business Information at Submission:

Hawaii Biotechnology Group Inc
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No