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POLIO/DENGUE CHIMERAE FOR DENGUE VACCINE DEVELOPMENT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
18957
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
18957
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: POLIO/DENGUE CHIMERAE FOR DENGUE VACCINE DEVELOPMENT
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

WE WILL CONSTRUCT HYBRID POLIO/DENGUE VIRUS GENOMES IN ORDER TO DEVELOP A VACCINE FOR DENGUE VIRUS. IN THE CHIMERIC GENOMES, ONE OF TWO DENGUE VIRUS ENVELOPE GENE FRAGMENTS WILL REPLACE SEGMENT OF THE POLIO VIRUS STRUCTURAL PROTEIN GENES. SUCH CHIMERAE WOULD HAVE THE ABILITY TO REPLICATE IN THE GUT AND TO PRODUCE LARGE QUANTITIES OF IMMUNOGEN WITHOUT INFECTIOUS PARTICLE FORMATION, UNLIKE ATTENUATED LIVE VACCINES OR RECOMBINANT VIRUS VECTORS. PHASE II RESEARCH WILL INCLUDE THE DETERMINATION OF THESE CHIMERIC GENOMES' ABILITY TO ELICIT A PROTECTIVE IMMUNERESPONSE IN MICE, THE CONSTRUCTION AND EVALUATION OF ADDITIONAL CHIMERIC GENOMES, AND THE EXPLORATION INTO PRODUCTION METHODS FOR ENCAPSULATED POLIO/DENGUE GENOMES IN THE ABSENCE OF HELPER VIRUS.

Principal Investigator:

Eileen T Nakano
8084865333

Business Contact:

Small Business Information at Submission:

Hawaii Biotechnology Group Inc
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No