Neutralizing Monoclonal Antibodies to Maitotoxin

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 25053	Program Year/Program: 1994 / SBIR
Agency Tracking Number: 25053	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI 96701-3900
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Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 1: Fiscal Year: 1994

Title: Neutralizing Monoclonal Antibodies to Maitotoxin

Agency: HHS

Contract: 1 R43 ES06863-1,

Award Amount: $80,250.00

Abstract:
Murine monoclonal antibodies which neutralize maitotoxin will be selected using a functionalassay that exploits the hemolytic action of maitotoxin. The resulting antibodies should be useful forseveral purposes. They will provide a means to measure the toxin content in crude extracts of fishtissues or dinoflagellate cultures by hemolysis neutralization assay. More importantly, neutralizingmonoclonal antibodies may provide a means to passively protect or reverse maitotoxin poisoning. Suchreagents could be humanized for clinical therapeutic applications. The antibodies may also be useful forother purposes including, studying the receptor pharmacology of maitotoxin and calcium ion channels;identifying and isolating maitotoxin-producing dinoflagellates; and, isolating purified maitotoxin byimmunoaffinity chromatography. Anti-idiotypic antibodies of those which neutralize maitotoxin shouldalso be of interest for a variety of analytical and biomedical applications.

Principal Investigator:
Gary Bignami
8084865333

Business Contact:

Small Business Information at Submission:

Hawaii Biotechnology Group,
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No