USA flag logo/image

An Official Website of the United States Government

Yeast Ty-Dengue Fusion Particles for Vaccines

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
24790
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
24790
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Yeast Ty-Dengue Fusion Particles for Vaccines
Agency: HHS
Contract: 1 R43 AI36245-1,
Award Amount: $80,591.00
 

Abstract:

Dengue viruses are a leading cause of morbidity and mortality throughout the tropics andsubtropics. It is estimated that more than 100 million people in the tropics are infected annually by thisvirus. This threat has now reached the southern United States with the arrival of the Aedes albopictusmosquito vector. Attempts to develop live attenuated dengue vaccines analogous to the yellow fevervaccine have yet to be successful. The proposal research is directed toward development of a definedsubunit dengue vaccine using yeast virus-like particles (VLPs) fused to peptides of the dengue envelope(E) glycoprotein. Such self-assembling VLPs are comprised of the protein product, p1, of the TYA geneof the yeast transposable element Ty. Fusion of dengue E cDNA fragments to the TYa gene will producep1-dengue fusion proteins. The resulting hybrid VLPs will require a single ultracentrifugation step forpurification and should present epitopes in a highly immunogenic form. During phase I, the feasibility ofthis approach will be tested by constructing a yeast TYA:dengue envelope peptide fusion gene andtesting expression, formation of hybrid VLPs, and immunoreactivity of the hybrid VLPs.

Principal Investigator:

John Ivy
8084865333

Business Contact:

Small Business Information at Submission:

Hawaii Biotechnology Group,
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No