USA flag logo/image

An Official Website of the United States Government

Expression of Antibodies in Neurospora

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
26303
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
26303
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Expression of Antibodies in Neurospora
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $66,474.00
 

Abstract:

The filamentous fungi, owing to their ability to secrete high levels of proteins, are attractive organisms for the expression and secretion of heterologous proteins of commercial and medical value. Secretion is a key element in their attraction, for secretion enables proper folding and processing of complex proteins and facilitates their purification. Proper folding and processing, simplified purification, and inexpensive culturing will translate into less expensive production. We have demonstrated secretion and processing of an enzymatically active mammalian protein, bovine preprochymosin, from "Neurospora crassa." In the proposed Phase I effort, we will test the feasibility of expressing in "Neurospora" a single chain antibody fragment (scFv) of established medical value and determine the ability of the recombinant scFv to recognize tumor cell surface antigen.

Principal Investigator:

John Marshall Ivy, Ph.d.
8084865333

Business Contact:

Small Business Information at Submission:

Hawaii Biotechnology Group,
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No