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Synthetic Receptor Libraries for Small Organic Molecules

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29259
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29259
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Synthetic Receptor Libraries for Small Organic Molecules
Agency: HHS
Contract: 1 R43 CA68893-01,
Award Amount: $100,000.00
 

Abstract:

We will develop high affinity, highly selective, synthetic receptors for small organic molecules. Achemistry approach will be used to produce an encoded, highly diverse, novel type of receptor librarconsists of three peptide arms symmetrically arranged about a rigid hydrophobic pocket. This librarythe ability to bind to a wide variety of target molecules in a wide variety of solvent systemss of iwould serve as substitutes for monoclonal antibodies in affinity chromatography, ELISA assays, and bAs a test case of this idea, we will screen the encoded library for receptors which selectively bindbaccatin III. Selected receptors will be resynthesized and further characterized.

Principal Investigator:

Paul Grothaus
80886

Business Contact:

Small Business Information at Submission:

Hawaii Biotechnology Group,
99-193 Aiea Heights Drive Aiea, HI 96701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No