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EVALUATION OF IMMUNOGENICITY : MALARIA SUBUNIT VACCINE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60454
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI051021
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: EVALUATION OF IMMUNOGENICITY : MALARIA SUBUNIT VACCINE
Agency: HHS
Contract: 1R43AI051021-01
Award Amount: $129,871.00
 

Abstract:

Malaria is a tropical parasitic disease that poses a significant health threat to much of the world. Each year, approximately 500 million become infected and more them 2 million die. There is great need to control the spread of the disease. One of the main focuses of malaria vaccine development has been on the use of recombinant proteins derived from the various developmental stages of the parasite. The goal of the proposed research is to enhance the immune response to MSP-1C- terminal subunits. Several clinically relevant adjuvants will be evaluated for the ability to elicit an appropriate immune response when combined with an MSP-1 p42 subunit. Additionally, the p42 subunit will be reengineered to contain conserved T-cell epitopes in an effort to focus the antibody response to the conserved p19 region. The ability to identify adjuvant formations that can potentiate an effective immune response to the MSP-1 p42 antigen and/or the ability to enhance the immune response to p19 by improved subunit design would facilitate the development of MSP-1 C-terminal subunits into viable malaria vaccine products.

Principal Investigator:

David E. Clements
8084865333
STAFF@HIBIOTECH.COM

Business Contact:

Tom Humphreys
8084865333
STAFF@HIBIOTECH.COM
Small Business Information at Submission:

HAWAII BIOTECH, INC.
HAWAII BIOTECH, INC. 99-193 AIEA HEIGHTS DR, STE 236 AIEA, HI 96701

EIN/Tax ID: 990214983
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No