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SELECTIVE ACTIVATION OF ANTIFUNGAL PRODRUGS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60512
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI050258
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: SELECTIVE ACTIVATION OF ANTIFUNGAL PRODRUGS
Agency: HHS
Contract: 1R43AI050258-01A1
Award Amount: $299,488.00
 

Abstract:

DESCRIPTION (Provided by applicant): The proposed research will investigate the feasibility of utilizing inherent properties of the infection site as a means to activate antifungal prodrugs selectively. Prodrug derivatives of an antifungal agent will be prepared and tested for their susceptibility to activation by conditions present at infection sites of C. albicans. Test compounds will be analyzed both in vitro and in vivo to determine their selectivity for the fungal infection. Promising leads will be those compounds which are both easily activated by these conditions and are resistant to activation in the normal mammalian physiological environment. Phase II will optimize the prodrug design based on our lead candidates and take this second generation design into preclinical testing.

Principal Investigator:

Sean Omalley
8084865333
STAFF@HIBIOTECH.COM

Business Contact:

David Watumull
8084865333
STAFF@HIBIOTECH.COM
Small Business Information at Submission:

HAWAII BIOTECH, INC.
HAWAII BIOTECH, INC. 99-193 AIEA HEIGHTS DR, STE 236 AIEA, HI 96701

EIN/Tax ID: 990214983
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No