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Recombinant Subunit Vaccine for Tick-Borne Encephalitis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71169
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
AI055225
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Recombinant Subunit Vaccine for Tick-Borne Encephalitis
Agency: HHS
Contract: 1R43AI055225-01A2
Award Amount: $422,170.00
 

Abstract:

DESCRIPTION (provided by applicant): Tick-borne encephalitis (TBE) is a neurological disease caused by Flaviviruses of the tick-borne encephalitis group and causes death in up to 60% of the individuals developing clinical symptoms. Survivors often show severe long-term neurological sequelae. In addition to natural infection via vector ticks in endemic areas, the highly infective viruses can be transmitted via food or in aerosolized form. Therefore, development of a TBE virus vaccine is a NIH high-priority biodefense project. Currently available commercial vaccines based on inactivated whole virus are not registered in the U.S., show considerable vaccination side-effects and do not provide complete protection against the more virulent Far-Eastern subtype. The specific goal of this project is to investigate the efficacy of recombinant subunit proteins used with clinically relevant adjuvants to achieve protection in the mouse model of TBE against both major subtypes of TBE viruses. Tested formulations will be single or combinations of antigens and selected modern adjuvants. Positive results will lead to multicomponent candidate vaccine testing in phase II also in a second animal model. A safe and efficacious vaccine based on recombinant subunit proteins would provide useful in protecting U.S. citizens from TBEV infection without the need of large-scale culture of highly infectious virus

Principal Investigator:

Axel T. Lehrer
8087921301
ALEHRER@HIBIOTECH.COM

Business Contact:

John Bower
8087921333
STAFF@HIBIOTECH.COM
Small Business Information at Submission:

HAWAII BIOTECH, INC.
99-193 AIEA HEIGHTS DRIVE, SUITE 200 AIEA, HI 96701

EIN/Tax ID: 990214983
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No