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PHASE I SAR ESTIMATION OF SKIN AND EYE IRRITATION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
433
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
433
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Enslein Research, Inc.
183 East Main Street Suite 1428 Rochester, NY 14604
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1985
Title: PHASE I SAR ESTIMATION OF SKIN AND EYE IRRITATION
Agency: HHS
Contract: N/A
Award Amount: $450,000.00
 

Abstract:

THIS PROPOSAL DEALS WITH THE DEVELOPMENTOF STRUCTURE ACTIVITY EQUATIONS (MODELS) FOR THE DRAIZE SKIN AND EYE IRRITANCY TESTS. THE APPLICANT HAS PREVIOUSLY DEVELOPED SUCH MODELS FOR RAT ORAL LD(50), MUTAGENICITY, CARCINOGENICITY, TERATOGENICITY, AND BIODEGRADABILITY. THE PRINCIPLES USED IN THE DEVELOPMENT OF THESE MODELS ARE TO BE APPLIED TO THE DEVELOPMENT OF SIMILAR MODELS FOR THE DRAIZE TESTS. IN THESE MODELS A SET OF CHEMICALS FOR WHICH THE ENDPOINTS HAVE BEEN MEASURED ARE USED TO FORM THE BASIS OF REGRESSION EQUATIONS. THE INDEPENDENT PARAMETERS INCLUDESUBSTRUCTURAL FRAGMENTS, AND PHYSICAL PARAMETERS SUCH AS OCTANOL-WATER PARTITION COEFFICIENT, MOLECULAR WEIGHT, MOLECULAR AREA AND VOLUME, MOLECULAR CONNECTIVITY INDICES, ETC. THE MAJORITY OF THE DATA FOR THE MODEL WILL BE DERIVEDFROM RTECS (REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES), WITH THE REMAINING DATA BEING OBTAINED FROM THEU. S. ARMY AND A DIRECETED SURVEY OF THE LITERATURE.

Principal Investigator:

Kurt Enslein
7165461464

Business Contact:

Small Business Information at Submission:

Health Designs Inc.
183 Main Street Rochester, NY 14604

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No