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DEVELOPMENTAL TOXICOLOGY STRUCTURE-ACTIVITY EQUATIONS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7288
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7288
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Enslein Research, Inc.
183 East Main Street Suite 1428 Rochester, NY 14604
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: DEVELOPMENTAL TOXICOLOGY STRUCTURE-ACTIVITY EQUATIONS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

RECENT ASSESSMENTS OF THE STATUS OF DEVELOPMENTAL TOXICOLOGYBY THE REGULATORY AND SCIENTIFIC COMMUNITIES HAVE IDENTIFIEDA NEED TO APPLY STRUCTURE-ACTIVITY RELATIONSHIPS (SARS) TO EXISTING TEST STRATEGIES. HEALTH DESIGNS, INC. HAS DEVELOPED A STATISTICAL SAR MODEL OF TERATOGENICITY BASED ON THE LITERATURE ON FRANK MALFORMATIONS IN MAMMALS. THIS MODEL IS BEING USED TO ESTIMATE THE PROBABILITY OF MALFORMATIONS FOR CHEMICALS THAT HAVE NOT YET BEEN TESTED. THE PURPOSE OF THE PROPOSED RESEARCH IS TO IMPROVE ON THE PRIOR WORK BY ASSEMBLING A MORE COHERENT AND DETAILED DATABASE OF DEVELOPMENTAL EFFECTS. SAR MODELS OF RELATED SETS OF CHEMICALS, CHEMICALS WITH COMMON PHARMACOLOGIC ACTIVITY, AND COMMON BIOCHEMICAL ACTIVITY WILL ALSO BE DEVELOPED. THE DATABASE AND THE SAR MODELS THUS DERIVED WOULD MATERIALLY ENHANCE THE ARMAMENTARIUM OF INDUSTRIAL TOXICOLOGISTS, HYGIENISTS, AND REGULATORS IN PINPOINTING EXPOSURES OF CONCERN. THE ESTIMATES OF DEVELOPMENTAL TOXICITY POTENTIAL COULD ALSO LEAD TO MORE FOCUSED DEVELOPMENTAL EFFECTS-TESTING OF POTENTIALLY HARMFUL CHEMICALS. THE PROPOSED RESEARCH COULD ALSO LEAD TO A REDUCTION IN THE NUMBERS OF ANIMALS USED IN REPRODUCTIVE EFFECTS-TESTING.

Principal Investigator:

Kurt enslein
7165461464

Business Contact:

Small Business Information at Submission:

Health Designs Inc
183 Main Street East Suite 50 Rochester, NY 14604

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No