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CYSTIC FIBROSIS (CF) IS A LETHAL AUTOSOMAL RECESSIVE DISEASEAFFECTING MAINLY…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4881
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4881
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Healthgenics Inc
4202 Gardendale Suite 102 San Antonio, TX 28229
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: CYSTIC FIBROSIS (CF) IS A LETHAL AUTOSOMAL RECESSIVE DISEASEAFFECTING MAINLY WHITE CHILDREN.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

CYSTIC FIBROSIS (CF) IS A LETHAL AUTOSOMAL RECESSIVE DISEASEAFFECTING MAINLY WHITE CHILDREN. THE RISK OF BEING A CARRIER OF THE CYSTIC FIBROSIS GENE IN THE WHITE POPULATION IS HIGH-APPROXIMATELY 5%. AFFECTED INDIVIDUALS WITH CYSTIC FIBROSIS CAN BE DIAGNOSED BY HIGH SWEAT CHLORIDE LEVELS WITHAPPROXIMATELY 98% RELIABILITY. HOWEVER, THOSE INDIVIDUALS WHO CARRY A SINGLE CYSTIC FIBROSIS GENE AND ARE POTENTIAL PARENTS OF CYSTIC FIBROSIS CHILDREN CANNOT BE DIAGNOSED. FOR EXAMPLE, NORMAL SIBLINGS OF CYSTIC FIBROSIS PATIENTS HAVE A 66.6% CHANCE OF CARRYING ONE OF THE DEFECTIVE GENES LEADING TO CYSTIC FIBROSIS. SUCH INDIVIDUALS AND OTHERS AREINTERESTED IN A DIAGNOSTIC TEST FOR DETECTING THE CYSTIC FIBROSIS GENE. THE COMMERCIAL APPLICATION OF DNA TECHNOLOGYTOWARD DEVELOPING A COMMERCIAL TEST FOR THE CYSTIC FIBROSIS GENE WILL BE THE LONG-TERM OBJECTIVE OF THIS PROJECT. PHASEI OF THIS PROJECT WILL IDENTIFY ONE OR MORE DNA POLYMORPH- ISMS THAT COSEGREGATE WITH THE CYSTIC FIBROSIS GENE BACAUSE OF THEIR PROXIMITY TO THE GENE ON A HUMAN CHROMOSOME. IDENTIFICATION OF SUITABLE DMA POLYMORPHISMS WILL BE USED TOSTUDY THE FEASIBILITY OF DETECTING THE SEGREGATION OF THE CFGENE IN FAMILIES FROM TEXAS, NEW YORK, AND MEXICO.

Principal Investigator:

Betty j dabney
PRINCIPAL INVESTIGATOR
5126909984

Business Contact:

Small Business Information at Submission:

Healthgenics Inc
4202 Gardendale Suite 102 San Antonio, TX 28229

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No