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POLYPORIN A: A NEW ANTI-AIDS IMMUNOREGULATORY DRUG

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7854
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7854
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Hipple Cancer Research
4100 S Kettering Boulevard Dayton, OH 45439
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: POLYPORIN A: A NEW ANTI-AIDS IMMUNOREGULATORY DRUG
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE PHARMACOLOGICAL ACTIVITIES OF AN EXTRACT OF POLYPORUS UMBELLATUS, A MUSHROOM INDIGENOUS TO CHINA, HAVE BEEN INVESTIGATED EXTENSIVELY BY THE NATIONAL INSTITUTES OF PHARMACEUTICAL RESEARCH & DEVELOPMENT. POLYPORIN A, A POLYSACCHARIDE PURIFIED FROM THE EXTRACT, HAS BEEN SHOWN TO HAVE IMMUNOMODULATORY AND ANTITUMOR ACTIVITIES AND IS CURRENTLY IN CLINICAL TRIALS IN CHINA. THE COMPOUND HAS BEEN SHOWN TO BE EFFECTIVE WHEN ADMINISTERED DURING OR AFTERCHEMOTHERAPY OR RADIOTHERAPY IN THE TREATMENT OF MALIGNANT TUMORS. THE HIPPLE CANCER RESEARCH CORPORATION HAS OBTAINEDQUANTITIES OF THIS COMPOUND SUFFICIENT FOR IN VITRO EVALUATION OF ITS IMMUNOHEMATOLOGICAL EFFECTS, OF ITS CLINICAL TOXICITY AND OF ITS POTENTIAL AS A COMMERCIAL PRODUCT. IN PHASE I OF THIS PROJECT, POLYPORIN A WILL BE EVALUATED TO DETERMINE ITS DIRECT IMMUNOMODULATORY EFFECT ON CELLS OF THE IMMUNE SYSTEM. EFFECTS OF THE COMPOUND WILLALSO BE DETERMINED IN VITRO ON CELLS OF THE HEMATOPOIETIC SYSTEM. THE CYTOPROTECTIVE EFFECT OF THE COMPOUND WILL BE DETERMINED ON NORMAL HUMAN BONE MARROW IN THE PRESENCE OF ANTI-AIDS DRUGS. FINALLY, THE FEASIBILITY OF UTILIZING POLYPORIN A AS AN ANTI-AIDS AGENT OR ADJUVANTAL AGENT WILL BE ESTABLISHED. IN PHASE II OF THE PROJECT, POLYPORIN A, IF FOUND TO SHOW SUFFICIENT PROMISE, WILL BE BROUGHT FORTH IN A TECHNOLOGY TRANSFER FASHION TO THE ETHICAL PHARMACEUTICAL INDUSTRY FOR PURCHASE AND USE IN CLINICAL IMMUNOHEMATOLOGY.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Hipple Cancer Research Center
4100 S Kettering Blvd Dayton, OH 45439

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No