USA flag logo/image

An Official Website of the United States Government

EFFECTS OF A BLOOD CELL GROWTH FACTOR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11128
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
11128
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Hipple Cancer Research
4100 S Kettering Boulevard Dayton, OH 45439
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1992
Title: EFFECTS OF A BLOOD CELL GROWTH FACTOR
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE HEMATOPOIETIC ACTIVITIES OF CORDYCEPS SINENSIS (CS), A RARE CHINESE FUNGUS, ARE KNOWN. RECENTLY, CS HAS BEEN SHOWN TO HAVE ADJUVANT EFFECTS WHEN ADMINISTERED TO PATIENTS WITH HEMATOLOGIC DISEASES AND TO CANCER PATIENTS DURING OR AFTER CHEMOTHERAPY OR RADIOTHERAPY. CS HAS BEEN SHOWN TO HAVE MULTIPLE BIOLOGICAL ACTIVITIES INCLUDING ENHANCEMENT OF IL-2 AND HEMATOPOIETIC GROWTH FACTOR PRODUCTION, AND STIMULATION OF NATURAL KILLER CELLS AND MACROPHAGES. THESE RESULTS SUGGEST THAT CS POSSESSES HEMATOPOIETIC STIMULATIVE OR IMMUNOPOTENTIATING FUNCTIONS. THE HIPPLE CANCER RESEARCH CORPORATION HAS OBTAINED QUANTITIES OF THIS NATIVE CHINESE MEDICINAL FUNGUS SUFFICIENT FOR IN VITRO EVALUATION OF ITS IMMUNOHEMATOLOGICAL AND ADJUVANT EFFECTS ON HUMAN CELLS. IN PHASE I, FRACTIONS OF CS WILL BE SCREENED FOR ACTIVITY IN IN VITRO HEMATOPOIETIC AND IMMUNOLOGIC ASSAYS USING HUMAN BONE MARROW OR PERIPHERAL BLOOD CELLS. THE EFFECTS OF CS FRACTIONS ON THE EXPRESSION OF HEMATOPOIETIC GROWTH FACTORS AND CYTOKINES WILL BE DETERMINED. IN PHASE II, CS COMPONENTS FOUND TO BE ACTIVE WILL BE PURIFIED TO HOMOGENEITY, ANALYZED BIOCHEMICALLY, AND EVALUATED QUANTITATIVELY IN APPROPRIATE HEMATOPOIETIC AND IMMUNOLOGICAL ASSAYS. IF FOUND TO SHOW SUFFICIENT PROMISE, THE GENES CODING THE ACTIVE COMPONENTS WILL BE CLONED FOR RECOMBINANT DNA PRODUCTION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Hipple Cancer Research Center
4100 S Kettering Blvd Dayton, OH 45439

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No