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MONOCLONAL AND POLYCLONAL MAGAKARYOCYTE CSF ANTIBODIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19093
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
19093
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Hipple Cancer Research
4100 S Kettering Boulevard Dayton, OH 45439
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1993
Title: MONOCLONAL AND POLYCLONAL MAGAKARYOCYTE CSF ANTIBODIES
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE PRODUCTION OF MEGAKARYOCYTES FROM PROGENITOR CELLS IN THE MARROW CAN BE STIMULATED BY A LINEAGE-SPECIFIC FACTOR-MEGAKARYOCYTE COLONY-STIMULATING FACTOR (MEG-CSF). THE LINEAGE-SPECIFIC STIMULATION OF MEGAKARYOCYTES BY MEG-CSF AND SUBSEQUENT INCREASE IN PLATELET NUMBER HAS GREAT CLINICAL SIGNIFICANCE IN TREATING THROMBOCYTOPENIA RESULTING FROM ANTI-CANCER OR ANTI-HIV THERAPIES. THE PRODUCTION OF POLYCLONAL AND MONOCLONAL ANTIBODIES TO MEG-CSF WOULD FACILITATE THE PURIFICATION OF MEG-CSF BY AFFINITY CHROMOTOGRAPHY, AND THE IDENTIFICATION OF RECOMBINANT CLONES EXPRESSING MEG-CSF CDNA. IN ADDITION, SUCH ANTIBODIES WILL ENABLE THE DEVELOPMENT OF ASSAYS, SUCH AS AN ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA), TO DETERMINE SERUM OR URINE MEG-CSF LEVELS IN THOSE PATIENTS UNDERGOING CHEMOTHERAPY OR WHO HAVE THROMBOCYTOPENIA FROM OTHER CAUSES. RABBITS WILL BE IMMUNIZED TO OBTAIN POLYCLONAL ANTIBODIES AND BOTH IN VITRO AND IN VIVO IMMUNIZATION OF MICE WILL BE PERFORMED FOR MONOCLONAL ANTIBODY PRODUCTION.

Principal Investigator:

Martin J Murphy Jr
5132997120

Business Contact:

Small Business Information at Submission:

Hipple Cancer Research Center
4100 South Kettering Boulevard Dayton, OH 45439

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No