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Company Information:

Company Name: HOWARD M. SHAPIRO, MD, P.C.
City: WEST NEWTON
State: MA
Zip+4: 02465 2513
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,282,590.00 15
SBIR Phase II $2,791,732.00 5

Award List:

THE PRACTICAL UTILITY OF MULTISTATION FLOW CYTOMETRY IS PRESENTLY LIMITED BY THE HIGH COST AND COMPLEXITY OF AVAILABLE APPARATUS.

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency: DOE
Principal Investigator: Howard m. shapiro , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
The practical utility of multistation flow cytometry is presently limited by the high cost and complexity of available apparatus. more widespread use of the technology for biological analysis would be possible if simpler instruments, incorporating less expensive components, could be used to do tasks… More

FLOW CYTOMETRY-IMPROVING COST-EFFECTIVENESS

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M Shapiro , Principal Investigator
Award Amount: $48,000.00

OPTIMIZING MULTIPARAMETER FLOW CYTOMETRY OF TUMOR CELLS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard m shapiro md
Award Amount: $44,000.00
Abstract:
Flow cytometry of such parameters as dna, rna, surface and/or internal antigen, and total protein content of tumor cells or nuclei is widely used in cancer research and is finding increasing clinical application. useful informationabout the biology of normal and abnormal cellular development, the… More

FLOW CYTOMETRY-IMPROVING COST-EFFECTIVENESS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Howard M Shapiro , Principal Investigator
Award Amount: $485,000.00
Abstract:
Flow cytometry is used for the counting, sizing and bio- chemical characterization of single cells and has become increasingly important in cell biology in general and in studies of cellular immunity and cancer in particular. the complexity and cost of the most modern apparatus have restricted the… More

IMPROVEMENTS IN FLOW CYTOMETRY OF BACTERIA AND VIRUSES

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M Shapiro
Award Amount: $48,424.00

IMPROVEMENTS IN FLOW CYTOMETRY OF BACTERIA AND VIRUSES

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator: Howard M Shapiro
Award Amount: $488,974.00
Abstract:
Several approaches to increasing the sensitivity of flow cytometry for the detection and characterization of small bacteria and large virus particles will be explored, including a water-immersed flow chamber, a laser doppler light-scatter detector system, front-end electronics incorporating source… More

NEW APPROACHES TO FLOW SORTING OF CHROMOSOMES

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Shapiro, Howard M , Principal Investigator
Award Amount: $47,754.00

A NONINVASIVE TEST FOR LEAD EXPOSURE AND IRON DEFICIENCY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M Shapiro
Award Amount: $49,904.00
Abstract:
Environmental and occupational exposure to lead place large numbers of children and adults at risk of lead poisoining. because the central nervous system toxicity of lead may be irreversible, its is desirable to screen populations at risk for increased lead absorption in order to detect otherwise… More

A RAPID CYTOMETRIC ASSAY FOR LYMPHOCYTE ACTIVATION

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M Shapiro
Award Amount: $49,866.00

NEW APPROACHES TO FLOW SORTING OF CHROMOSOMES

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Shapiro, Howard M , Principal Investigator
Award Amount: $389,114.00
Abstract:
Purification of individual chromosomes by flow sorting is often a first step in defining the structure of normal and abnormal human genes. the polymerase chain reaction (pcr) drastically reduces the amount of sample required for isolation of chromosomal dna, making it feasible to develop simpler,… More

A RAPID CYTOMETRIC ASSAY FOR LYMPHOCYTE ACTIVATION

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Howard M Shapiro
Award Amount: $694,125.00
Abstract:
Rapid cytometric assays for lymphocyte activation have many potential clinical applications, including evaluation of cellular immune dysfunction in hiv infections and cancer, autoimmune disease process activity assessment, tissue typing, and monitoring of transplant recipients for early signs of… More

CYTOMETRY OF BASOPHILS FOR ALLERGY TESTING

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $78,129.00

INEXPENSIVE MODULAR FLOW CYTOMETERS--A NEW GENERATION

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Shapiro, Howard M
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Shapiro Howard M
Award Amount: $734,519.00

CYTOMETRY-AIDED DEVELOPMENT OF ANTIMICROBIAL AGENTS

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M. Shapiro
Award Amount: $81,525.00
Abstract:
DESCRIPTION (provided by applicant): There has recently been an alarming increase in infections due to bacteria resistant to all available antibiotics. Tetracycline resistance is typically mediated by efflux pumps; tetracycline derivatives which inhibit them may be used in… More

HIGH-PRECISION FLOW CYTOMETRY OF BACTERIA AND VIRUSES

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M. Shapiro
Award Amount: $94,860.00
Abstract:
DESCRIPTION (provided by applicant): Most flow cytometers are optimized for analysis of eukaryotic cells. Measurements of bacteria and viruses in conventional instruments are limited by photoelectron statistics; some microbial constituents, and smaller microbes, may thus be undetectable or not… More

CYTOMETRIC TUBERCULOSIS DETECTION AND SENSITIVITY TESTS

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M. Shapiro
Award Amount: $96,573.00
Abstract:
DESCRIPTION (provided by applicant): Tuberculosis (TB) remains one of the deadliest diseases, with more than 8 million new cases and approximately 3 million deaths worldwide annually. Since the 1980s, increased incidence of active TB in HIV-infected individuals and the emergence of drug-resistant… More

AFFORDABLE RAPID BACTERIAL DETECTION IN STORED PLATELETS

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M. Shapiro
Award Amount: $96,573.00
Abstract:
DESCRIPTION (provided by applicant): Blood platelets collected for transfusion must be stored at room temperature to maximize their survival in a functional state. Bacteria may be introduced into stored platelets during the collection process or as a result of unnoticed bacteremia in the donor(s);… More

CYTOMETRIC CD4 COUNTING - A MINIMALIST APPROACH

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M. Shapiro
Award Amount: $97,753.00
Abstract:
DESCRIPTION (provided by applicant): In late 1981, Gottlieb et al described an apparently new immunodeficiency syndrome in homosexual men living in the United States. We now know the syndrome as AIDS (Acquired Immune Deficiency Syndrome), recognize the re trovirus HIV (Human Immunodeficiency Virus)… More

RAPID AFFORDABLE TB DRUG SUSCEPTIBILITY TESTING

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Howard M. Shapiro
Award Amount: $299,229.00
Abstract:
DESCRIPTION (provided by applicant): The World Health Organization (WHO) estimates that 8.9 million cases of TB occurred in 2004, with 3.9 million of these representing the most infectious, smear-positive, form. Of the estimated 1.7 million deaths, over 26 0,000 occurred in HIV-infected individuals;… More