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Company Information:

Company Name:
HOWARD M. SHAPIRO, MD, P.C.
Address:
283 HIGHLAND AVE.
WEST NEWTON, MA 02465 2513
Phone:
N/A
URL:
N/A
EIN:
42592009
DUNS:
877063982
Number of Employees:
N/A
Woman-Owned?:
No
Minority-Owned?:
No
HUBZone-Owned?:
No

Commercialization:

Has been acquired/merged with?:
N/A
Has had Spin-off?:
N/A
Has Had IPO?:
N/A
Year of IPO:
N/A
Has Patents?:
N/A
Number of Patents:
N/A
Total Sales to Date $:
$ 0.00
Total Investment to Date $
$ 0.00
POC Title:
N/A
POC Name:
N/A
POC Phone:
N/A
POC Email:
N/A
Narrative:
N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,282,590.00 15
SBIR Phase II $2,791,732.00 5

Award List:

THE PRACTICAL UTILITY OF MULTISTATION FLOW CYTOMETRY IS PRESENTLY LIMITED BY THE HIGH COST AND COMPLEXITY OF AVAILABLE APPARATUS.

Award Year / Program / Phase:
1984 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
DOE
Principal Investigator:
Howard m. shapiro , PRINCIPAL INVESTIGATOR
Abstract:
The practical utility of multistation flow cytometry is presently limited by the high cost and complexity of available apparatus. more widespread use of the technology for biological analysis would be possible if simpler instruments, incorporating less expensive components, could be used to do tasks… More

FLOW CYTOMETRY-IMPROVING COST-EFFECTIVENESS

Award Year / Program / Phase:
1986 / SBIR / Phase I
Award Amount:
$48,000.00
Agency:
HHS
Principal Investigator:
Howard M Shapiro , Principal Investigator
Abstract:
N/a

OPTIMIZING MULTIPARAMETER FLOW CYTOMETRY OF TUMOR CELLS

Award Year / Program / Phase:
1987 / SBIR / Phase I
Award Amount:
$44,000.00
Agency:
HHS
Principal Investigator:
Howard m shapiro md
Abstract:
Flow cytometry of such parameters as dna, rna, surface and/or internal antigen, and total protein content of tumor cells or nuclei is widely used in cancer research and is finding increasing clinical application. useful informationabout the biology of normal and abnormal cellular development, the… More

FLOW CYTOMETRY-IMPROVING COST-EFFECTIVENESS

Award Year / Program / Phase:
1988 / SBIR / Phase II
Award Amount:
$485,000.00
Agency:
HHS
Principal Investigator:
Howard M Shapiro , Principal Investigator
Abstract:
Flow cytometry is used for the counting, sizing and bio- chemical characterization of single cells and has become increasingly important in cell biology in general and in studies of cellular immunity and cancer in particular. the complexity and cost of the most modern apparatus have restricted the… More

IMPROVEMENTS IN FLOW CYTOMETRY OF BACTERIA AND VIRUSES

Award Year / Program / Phase:
1990 / SBIR / Phase I
Award Amount:
$48,424.00
Agency:
HHS
Principal Investigator:
Howard M Shapiro
Abstract:
N/a

IMPROVEMENTS IN FLOW CYTOMETRY OF BACTERIA AND VIRUSES

Award Year / Program / Phase:
1991 / SBIR / Phase II
Award Amount:
$488,974.00
Agency:
HHS
Principal Investigator:
Howard M Shapiro
Abstract:
Several approaches to increasing the sensitivity of flow cytometry for the detection and characterization of small bacteria and large virus particles will be explored, including a water-immersed flow chamber, a laser doppler light-scatter detector system, front-end electronics incorporating source… More

NEW APPROACHES TO FLOW SORTING OF CHROMOSOMES

Award Year / Program / Phase:
1991 / SBIR / Phase I
Award Amount:
$47,754.00
Agency:
HHS
Principal Investigator:
Shapiro, Howard M , Principal Investigator
Abstract:
N/a

A NONINVASIVE TEST FOR LEAD EXPOSURE AND IRON DEFICIENCY

Award Year / Program / Phase:
1992 / SBIR / Phase I
Award Amount:
$49,904.00
Agency:
HHS
Principal Investigator:
Howard M Shapiro
Abstract:
Environmental and occupational exposure to lead place large numbers of children and adults at risk of lead poisoining. because the central nervous system toxicity of lead may be irreversible, its is desirable to screen populations at risk for increased lead absorption in order to detect otherwise… More

A RAPID CYTOMETRIC ASSAY FOR LYMPHOCYTE ACTIVATION

Award Year / Program / Phase:
1992 / SBIR / Phase I
Award Amount:
$49,866.00
Agency:
HHS
Principal Investigator:
Howard M Shapiro
Abstract:
N/a

NEW APPROACHES TO FLOW SORTING OF CHROMOSOMES

Award Year / Program / Phase:
1993 / SBIR / Phase II
Award Amount:
$389,114.00
Agency:
HHS
Principal Investigator:
Shapiro, Howard M , Principal Investigator
Abstract:
Purification of individual chromosomes by flow sorting is often a first step in defining the structure of normal and abnormal human genes. the polymerase chain reaction (pcr) drastically reduces the amount of sample required for isolation of chromosomal dna, making it feasible to develop simpler,… More

A RAPID CYTOMETRIC ASSAY FOR LYMPHOCYTE ACTIVATION

Award Year / Program / Phase:
1995 / SBIR / Phase II
Award Amount:
$694,125.00
Agency:
HHS
Principal Investigator:
Howard M Shapiro
Abstract:
Rapid cytometric assays for lymphocyte activation have many potential clinical applications, including evaluation of cellular immune dysfunction in hiv infections and cancer, autoimmune disease process activity assessment, tissue typing, and monitoring of transplant recipients for early signs of… More

CYTOMETRY OF BASOPHILS FOR ALLERGY TESTING

Award Year / Program / Phase:
1996 / SBIR / Phase I
Award Amount:
$78,129.00
Agency:
HHS
Principal Investigator:
Abstract:
N/a

INEXPENSIVE MODULAR FLOW CYTOMETERS--A NEW GENERATION

Award Year / Program / Phase:
1998 / SBIR / Phase I
Award Amount:
$100,000.00
Agency:
HHS
Principal Investigator:
Shapiro, Howard M
Abstract:
N/a

N/A

Award Year / Program / Phase:
1999 / SBIR / Phase II
Award Amount:
$734,519.00
Agency:
HHS
Principal Investigator:
Shapiro Howard M
Abstract:
N/a

CYTOMETRY-AIDED DEVELOPMENT OF ANTIMICROBIAL AGENTS

Award Year / Program / Phase:
2001 / SBIR / Phase I
Award Amount:
$81,525.00
Agency:
HHS
Principal Investigator:
Howard M. Shapiro
Abstract:
DESCRIPTION (provided by applicant): There has recently been an alarming increase in infections due to bacteria resistant to all available antibiotics. Tetracycline resistance is typically mediated by efflux pumps; tetracycline derivatives which inhibit them may be used in… More

HIGH-PRECISION FLOW CYTOMETRY OF BACTERIA AND VIRUSES

Award Year / Program / Phase:
2004 / SBIR / Phase I
Award Amount:
$94,860.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Most flow cytometers are optimized for analysis of eukaryotic cells. Measurements of bacteria and viruses in conventional instruments are limited by photoelectron statistics; some microbial constituents, and smaller microbes, may thus be undetectable or not… More

CYTOMETRIC TUBERCULOSIS DETECTION AND SENSITIVITY TESTS

Award Year / Program / Phase:
2005 / SBIR / Phase I
Award Amount:
$96,573.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Tuberculosis (TB) remains one of the deadliest diseases, with more than 8 million new cases and approximately 3 million deaths worldwide annually. Since the 1980s, increased incidence of active TB in HIV-infected individuals and the emergence of drug-resistant… More

AFFORDABLE RAPID BACTERIAL DETECTION IN STORED PLATELETS

Award Year / Program / Phase:
2005 / SBIR / Phase I
Award Amount:
$96,573.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Blood platelets collected for transfusion must be stored at room temperature to maximize their survival in a functional state. Bacteria may be introduced into stored platelets during the collection process or as a result of unnoticed bacteremia in the donor(s);… More

CYTOMETRIC CD4 COUNTING - A MINIMALIST APPROACH

Award Year / Program / Phase:
2007 / SBIR / Phase I
Award Amount:
$97,753.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): In late 1981, Gottlieb et al described an apparently new immunodeficiency syndrome in homosexual men living in the United States. We now know the syndrome as AIDS (Acquired Immune Deficiency Syndrome), recognize the re trovirus HIV (Human Immunodeficiency Virus)… More

RAPID AFFORDABLE TB DRUG SUSCEPTIBILITY TESTING

Award Year / Program / Phase:
2008 / SBIR / Phase I
Award Amount:
$299,229.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): The World Health Organization (WHO) estimates that 8.9 million cases of TB occurred in 2004, with 3.9 million of these representing the most infectious, smear-positive, form. Of the estimated 1.7 million deaths, over 26 0,000 occurred in HIV-infected individuals;… More