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A RAPID CYTOMETRIC ASSAY FOR LYMPHOCYTE ACTIVATION

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 18919
Amount: $694,125.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
283 Highland Avenue
West Newton, MA 02165
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Howard M Shapiro
 (617) 965-6044
Business Contact
Phone: () -
Research Institution
N/A
Abstract

RAPID CYTOMETRIC ASSAYS FOR LYMPHOCYTE ACTIVATION HAVE MANY POTENTIAL CLINICAL APPLICATIONS, INCLUDING EVALUATION OF CELLULAR IMMUNE DYSFUNCTION IN HIV INFECTIONS AND CANCER, AUTOIMMUNE DISEASE PROCESS ACTIVITY ASSESSMENT, TISSUE TYPING, AND MONITORING OF TRANSPLANT RECIPIENTS FOR EARLY SIGNS OF GRAFT REJECTION. WE WILL DEVELOP REPRODUCIBLE, STANDARDIZED METHODS WHICH CAN BE IMPLEMENTED ON THE CURRENT GENERATION OF CLINICAL FLOW CYTOMETERS, AS WELL AS ON NEWER CYTOMETRIC APPARATUS NOW COMING INTO USE. MULTI-PARAMETER FLOW CYTOMETRY WILL BE USED TO ANALYZE AND CORRELATE CHANGES IN CYTOPLASMIC PH, FLOURESCEIN FLOURESCENCE POLARIZATION, AND ACTIVATION ANTIGEN EXPRESSION OF HUMAN PERIPHERAL T-LYMPHOCYTES DURING THE FIRST 24 HOURS FOLLOWING ACTIVATION BY THE POLYCLONAL MITOGEN PHYTOHEMAGGLUTININ OR BY ALLOANTIGEN IN THE MIXED LYMPHOCYTE REACTION. IT IS LIKELY THAT THE STUDIES WILL YIELD USABLE ASSAYS BASED ON PH MEASUREMENT AND ACTIVATION ANTIGEN DETECTION.

* Information listed above is at the time of submission. *

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