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AMYLASE ISOZYME DETERMINATION WITH MONOCLONAL ANTIBODIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2997
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
2997
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Humagen Inc
1500 Avon St Ext Charlottesville, VA 22901
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1987
Title: AMYLASE ISOZYME DETERMINATION WITH MONOCLONAL ANTIBODIES
Agency: HHS
Contract: N/A
Award Amount: $188,000.00
 

Abstract:

THE ULTIMATE GOAL OF THIS RESEARCH IS TO DEVELOP A DIAGNOSTIC KIT WHICH WILL PERMIT EASY AND RAPID IDENTIFICATION OF OVARIAN AMYLASE. THIS AMYLASE ISOZYME APPEARS TO BE A GOOD INDICATOR FOR OVARIAN CANCER. IN ADDITION, MONOCLONAL ANTIBODIES WILL BE PRODUCED WHICH WILL ENABLE CLINICAL INVESTIGATORS RELIABLY TO DETECT THE AMOUNTS OF SALIVARY, PANCREATIC, AND OVARIAN AMYLASES IN PATIENT SPECIMENS. IT IS ANTICIPATED THAT IT WILL BE POSSIBLE TO GENERATE MONOCLONALS WHICH WILL DETECT SPECIFIC ISOELECTRIC VARIANTS OF EACH ISOZYME. DURING PHASE I MONOCLONAL ANTIBODIES SPECIFIC FOR EACH ISOENZYME WILL BE GENERATED. THEY WILL FORM THE BASIS FOR KIT DEVELOPMENT AND CLINICAL TESTING DURING PHASE II. SUCH A KIT PERMITTING DIRECT EVALUATION OF AMYLASE ISOZYME LEVELS SHOULD PROVE SUPERIOR TO CURRENT METHODOLOGIES WHICH ARE EITHER TIME CONSUMING OR WHICH RELY ON INHIBITORS FOR DISTINGUSHING ISOZYMES. AT PRESENT ACTIVITY MEASUREMENTS CANNOT DISTINGUISH OVARIAN FROM SALIVARY ISOZYMES.

Principal Investigator:

Michael P. Woodward
Principal Investigator
8042955912

Business Contact:

Small Business Information at Submission:

Humagen Inc.
1500 Avon St. Ext. Charlottesville, VA 22901

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No