78128S Transmission electron microscopy is uniquely able to image the internal structure of materials at resolutions in the nanometer to sub-Angstrom scale, and as such is a primary tool in materials science and nanotechnology research. Crucial to obtaining these images, however, is the ability to… More

78165S Electron tomography can provide three-dimensional image information about the internal structure of solid-state and biological materials, making it a crucial tool for nanotechnology and life science research, as well as semiconductor failure analysis. Existing methods for producing tomograms… More

Transmission electron microscopy (TEM) is the primary methodology for characterizing the internal structure of materials at the nanometer to sub-Angstrom scale. In the TEM, image formation results from the scattering of an incident electron wave by the atoms inside the crystal, and results in the… More

Three-dimensional electron tomography can render images of the internal structure of solid-state and biological materials at the nanometer scale, and is finding increased application in nanotechnology, semiconductor industries, and the life sciences. However, current systems cannot acquire all the… More

Electron microscopes are important tools for materials research. However, the current state of the art for the heating and cooling stages of these microscopes has five major limiting factors: (1) temperature limitation to 1600C, (2) substantial thermal drift, (3) vibration induced from cooling… More

DESCRIPTION (provided by applicant): The long term objective of our application is to develop hardware and procedures that will allow researchers to better understand the function of the cell. Our specific aim is to provide a system that will allow researchers to better prepare frozen hydrated… More

Electron microscopy of specimen in liquid has recently been demonstrated by Niels de Jong at Oak Ridge National Laboratory (ORNL). A sample was enclosed in a liquid compartment with electron transparent windows and imaged using a scanning transmission electron microscope (STEM). Expanding on this… More

Project Summary The long term objective of our application is to develop hardware and procedures that will allow researchers to better understand the function of the cell. Our specific aim is to provide a system that will allow researches to better prepare frozen hydrated specimens for study via… More

With the development of new nanostructured materials, there is an increasing need to quantify their basic properties. The small size scales of the materials complicate the adaptation of existing experimental approaches and require new instruments to perform basic measurements. This project will… More

The addition of continuous fluid flow through a set of electron transparent windows in a transmission electron microscope (TEM) or scanning transmission electron microscope (STEM) will provide the ability to image reactions that occur at the nanoscale. In particular, liquid STEM presents a unique in… More

DESCRIPTION (provided by applicant): The objective of our application is to develop hardware and procedures that will allow researchers to practically utilize phase plates in the back focal plane of the objective lens in a Transmission Electron Microscope. Use of precisely positioned phase plates… More

DESCRIPTION (provided by applicant): Transmission electron microscope (TEM) tomography provides three-dimensional images at the nanometer scale. It is a mainstream technique in biological electron microscopy, and is rapidly finding applications in the semi conductor and nanotechnology industries. In… More

Researchers are currently hindered from observing dynamic liquid-liquid and liquid-solid interactions in transmission electron microscopes (TEMs) and scanning transmission electron microscopes (STEMs). Yet, solid-state materials and fluids interact in many important ways. For example, solid-state… More

The Department of Energy supports the microcharacterization of materials via Transmission Electron Microscopy (TEM) as a core research area. This project will expand the utility of TEM by developing an environmental holder for liquid and gaseous environments. While the proposed effort will focus… More

The DOE is seeking a capability that will allow samples in electron microscopes to be subjected to high magnetic fields. Some of the most exciting scientific developments are being made in the field of nanoscale magnetic materials, for example the discovery of the giant magneto resistance (GMR) and… More

Solid-state and biological materials interact with fluids in many important ways. Solid-state nanoparticles are formed via solution based synthesis and biological cells exist live only in a fluid environment. In Phase I, we demonstrated a method to image

This Small Business Innovation Research (SBIR) Phase I project will combine the two primary experimental methods for characterization in nanotechnology, atomic force microscopy (AFM) and in-situ transmission electron microscopy (TEM), into one tool. The AFM allows high-resolution images to be made… More

This Small Business Innovation Research Phase I project will develop a microfluidic in-situ Transmission Electron Microscope (TEM) specimen holder with accurate temperature and pressure measurement and control abilities. The inability to dynamically image materials at atomic resolutions in changing… More