The application of a in vitro model system for the isolation and propagation of cells having specific tumor properties will be demonstrated. the model system will also be utilized to test different media formulations as to general applicability for growing carcinoma cells in vitro. during phase i… More

The objective of this sbir is to develop monoclonal antibodies specific for prostate carcinoma antigens. these antibodies would be developed in phase iii: 1.) as a screening test for early diagnosis of prostate cancer by identifying prostate tumor antigens shed into the serum, 2.) in imaging and… More

The specific aims of this project are twofold. a hat-sensitive, non-immunoglobulin secreting human myeloma cell line will be developed and characterized for specific application to human hybridoma production and a tissue culture medium will be developed (not requiring conditioned medium or fetal… More

The measurement of glycosylated hemoglobin is probably the best means of assessing glucose control over time in diabetics. it now appears there is inverse correlation between the control of glucose metabolism and complications of the disease in that well controlled diabetics do much better. the… More

The glycoprotein hormone erythropoietin is a prime regulator of red cell production in higher organisms. the hormone is produced in the kidney in response to hypoxia, for example, as a result of anemia. it would be of great value to have an immunoassay to monitor erythropoietin levels in people… More

Lipoproteins are high molecular weight water-soluble complexes composed of lipid and one or more specific proteins. they are grouped according to their density as determined by ultracentrifugation. plasma low density lipoproteins (ldl) contain approximately 75% lipid and 25% protein and function as… More