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FERTILE PERIOD PREDICTION WITH A TRIF BIOSENSOR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19174
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
19174
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IA, Inc.
P.O. Box 1306 Ann Arbor, MI 48106
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1994
Title: FERTILE PERIOD PREDICTION WITH A TRIF BIOSENSOR
Agency: HHS
Contract: N/A
Award Amount: $530,102.00
 

Abstract:

ALTHOUGH SEVERAL OTC OVULATION TESTS EXIST, NON ARE SUITABLE FOR CONTRACEPTION APPLICATIONS BECAUSE THEY DETECT LUTEINIZING HORMONE (LH) WHICH EXHIBITS A PEAK PRECEDING OVULATION BY ONLY 16-36 HOURS. THIS RESEARCH WILL DEVELOP A FERTILE PERIOD PREDICTION SYSTEM BASED UPON THE PRESENCE OF AN INCREASE IN URINARY ESTRONE-3-GLUCURONIDE (E1-G) 5 DAYS PRIOR TO OVULATION AND AN INCREASE IN PREGNANEDIOL GLUCURONIDE (PD-G) FOLLOWING OVULATION. THE MEAN VALUE OF E1-G RISES BY A FACTOR OF THREE TWO DAYS PRIOR TO THE LH PEAK, BUT ITS MROE GRADUAL RISE REQUIRES A MORE QUANTITATIVE DETECTION DEVICE THAN THE ON OR OFF COLOR OTC LH TESTS. THIS OBSTACLE WILL BE OVERCOME BY EMPLOYING A NOVEL, COMPETITIVE, IMMUNOASSAY-BASED, TOTAL INTERNAL REFLECTANCE FLUORESCENCE (TIRF) BIOSENSOR CONSISTING OF QUARTZ FIBER PROBES WHICH WILL MEASURE E1-G, AND PD-G AND AN ADDITIONAL FIBER WHICH WILL ENABLE CORRECTIONOF URINE VOLUME. THE DEVICE WILL DISPLAY A RED LIGHT DURING THE FERTILE PERIOD.

Principal Investigator:

Judith L Erb
3139959338

Business Contact:

Small Business Information at Submission:

Innovation Assocaites Inc.
Po Bxo 1306 Ann Arbor, MI 48106

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No