An adverse reaction to a drug which takes place while a patient is on medication is often impossible to diagnose accurately. the nature of the underlying reaction may have an immunologic, toxicologic, or pharmacologic basis. among the most notable immunologic reactions to drugs are those which give… More

Beta-endorphin (be) is a peptide composed of the 30 carboxyl-terminal residues of beta-lipotropin (blph). it has been shown to be a naturally occurring opiate, as well as to possess nonopiate related bioactivity. current assay techniques are inadequate due to lack of immunological specificity… More

The formation of dna-carcinogen adducts is an important environmental factor in carcinogenesis. recent techniques for isolation and characterization of deoxynucleoside-carcinogen adducts and subsequent immunoassay procedures can effectively detect these adducts from cell lysates in the range of 1… More

Platelet membrane glycoprotein iii (gpiii) is known to be the locus for the platelet alloantigen pla1. this antigen is a gene product of one allele of a bi-allelic system having the observed distribution of: pla1a1=0.69; pla1a2= 0.28; and pla2a2=0.03. exposure to the pla1 antigen can induce… More

Several investigators have implicated modified ribonucleosides, presumably modification products from transfer ribonucleic acids (trnas), as potential biological markers for cancer. elevated levels of these molecules have been quantitated in the serum or urine of cancer patients by high-performance… More