Photo-Linked Antibody Chelates for Tumor Imaging
1 R43 CA65299-01A1,
Light induced chemical reactions (so-called photochemical activation) can be done under mild conditare physiological for biologically active macromolecules. We have recently used such photo-chemistryorganic molecules to antibodies. The photolinker contain side chains which can act as chelaters forproposal is to use this technique to produce radiolabeled antibodies for tumor imaging through photochelated 111Indium3+. Preliminary experiments showed that the photolinker attaches in a specific fason immunoglobulins of different isotopes and specificities. Furthermore, it was demonstrated that phretain the full capacity to bind to antigen. In the present proposal we plan to produce radiolabeledagainst a mouse and a human B cell lymphoma cell line and to use these radiolabeled antibodies to imscintigraphic techniques. We expect to show that our photoactivation technique will produce radiolabcancers with superior tumor-uptake specificity. Such radiolabeled antibodies are much needed and valdiagnosis and therapy.
Small Business Information at Submission:
Principal Investigator:Beby Jayaram
2134 Nicholasville Road, Suite Lexington, KY 40503
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