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Photo-Linked Antibody Chelates for Tumor Imaging

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29197
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29197
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Immpheron, Inc.
5235 ATHENS BOONESBORO RD Lexington, KY 40509
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Photo-Linked Antibody Chelates for Tumor Imaging
Agency: HHS
Contract: 1 R43 CA65299-01A1,
Award Amount: $75,000.00
 

Abstract:

Light induced chemical reactions (so-called photochemical activation) can be done under mild conditare physiological for biologically active macromolecules. We have recently used such photo-chemistryorganic molecules to antibodies. The photolinker contain side chains which can act as chelaters forproposal is to use this technique to produce radiolabeled antibodies for tumor imaging through photochelated 111Indium3+. Preliminary experiments showed that the photolinker attaches in a specific fason immunoglobulins of different isotopes and specificities. Furthermore, it was demonstrated that phretain the full capacity to bind to antigen. In the present proposal we plan to produce radiolabeledagainst a mouse and a human B cell lymphoma cell line and to use these radiolabeled antibodies to imscintigraphic techniques. We expect to show that our photoactivation technique will produce radiolabcancers with superior tumor-uptake specificity. Such radiolabeled antibodies are much needed and valdiagnosis and therapy.

Principal Investigator:

Beby Jayaram
60657

Business Contact:

Small Business Information at Submission:

Immpheron, Inc.
2134 Nicholasville Road, Suite Lexington, KY 40503

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No