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Aromatic Dication Prodrugs for CNS Trypanosomiasis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71265
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
AI061870
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IMMTECH INTERNATIONAL, INC.
IMMTECH INTERNATIONAL, INC. 150 FAIRWAY DR, STE 150 VERNON HILLS, IL 60061 0186
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Aromatic Dication Prodrugs for CNS Trypanosomiasis
Agency: HHS
Contract: 1R43AI061870-01
Award Amount: $107,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The long-range research goal is to develop a new drug to treat secondary (central nervous system) stage human African trypanosomiasis. Previous SBIR supported research identified DB289, a methoxime prodrug of the aromatic dication furamidine, that is currently progressing in Phase lib clinical trials for treatment of early stage African sleeping sickness. DB289, however, is not curative in animal models of CNS stage trypanosomiasis. We have recently identified alkylamidoxime prodrugs of novel aza analogs of furamidine that are curative in a chronic mouse model of infection. The objective of this Phase I SBIR application is to synthesize sufficient quantities of six prodrugs to perform further efficacy, toxicity and metabolism studies. The specific aims are designed to permit selection of a lead candidate compound to enroll during Phase II research into advanced efficacy testing in a primate model of CNS infection and into formal preclinical toxicity testing. The research may lead to development of a potent, safe and economical new drug to treat this devastating protozoan parasitic infection currently estimated to be killing over 300,000 people in recent outbreaks in Africa.

Principal Investigator:

James L. Allen
8475730033
JALLEN@IMMTECH.BIZ

Business Contact:

T. Thompson
8475730033
STHOMPSON@IMMTECH.BIZ
Small Business Information at Submission:

IMMTECH INTERNATIONAL, INC.
IMMTECH INTERNATIONAL, INC. 150 FAIRWAY DR, STE 150 VERNON HILLS, IL 60061

EIN/Tax ID: 391523370
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No