The number of cases of human diarrhea attributed to cryptosporidium parvum has increased dramatically in the last decade. in immunocompromised individuals, most notablyaids patients, cryptosporidiosis can present as a fulminant and persistent diarrhea. there is currently no known chemotherapeutic… More

Cryptosporidium parvum is a significant human pathogen whose incidence has increased dramatically in the last decade and that currently infects approximatly 10% of aids patients inthe u.s. mortality due to this parasite exceeds 60% of infected immunocompromised patients. no therapeutic drugs are… More

Cryptosporidium parvum is a significant human pathogen for which no chemotherapy has been shown to be efficacious. the number of cases of human cryptosporidiosis has increased dramatically in the last decade, particularly in the population of immuno-compromised individuals. in the aids population,… More

Enterotoxigenic E. coli (ETEC) is among the most important agents involved in pediatric diarrhea anmost frequently encountered cause of illness in visitors to these regions. It is estimated that 16 mindustrialized nations travel to ETEC-endemic regions annually, and that 30-70% of these travelers… More

Bovine mastitis is a major economic loss for the dairy industry and indirectly a human hazard because treatment selects for antibiotic resistant bacteria. We propose to develop an novel anti-microbial therapy for dry cow mastitis based on Nisin that would break farmer's dependence on antibiotics… More

Johne's disease, caused by Mycobacterium paratuberculosis (M. para), is a chronic inflamatory bowel disease of ruminants. recent literature has fueled an as-yet unresolved debate about whether this organism is also the eitiological agent of at least some proportion of Crohn's Disease in humans.… More

The development of stategies and products to prevent the spread of antibiotic resistance is a national priority. A significant contributing factor in the rise of antibiotic resistance is the agricultural application of antibiotics which are used to treat human disease. We propose to… More

Developing strategies and products to prevent the spread of antibiotic resistance is a national priority. A significant contributing factor in the rise of antibiotic resistance is the use of antibiotics to treat diseases which are not life threatening. We propose to develop two novel anti-microbial… More