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THIS PROPOSAL IS FOR EXTENDING STUDIES RELATED TO THE EVALUATION OF POLYCATION…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
455
Program Year/Program:
1983 / SBIR
Agency Tracking Number:
455
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Immunogenics Corpon
1000 Seneca Street Seattle, WA 98101
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1983
Title: THIS PROPOSAL IS FOR EXTENDING STUDIES RELATED TO THE EVALUATION OF POLYCATION HEXADIMETHRINE (HDM) AND ITS COMPONENTS AS ANTICANCER AGENTS.
Agency: HHS
Contract: N/A
Award Amount: $29,820.00
 

Abstract:

THIS PROPOSAL IS FOR EXTENDING STUDIES RELATED TO THE EVALUATION OF POLYCATION HEXADIMETHRINE (HDM) AND ITS COMPONENTS AS ANTICANCER AGENTS. THESE INVESTIGATORS HAVE DEMONSTRATED A DIFFERENTIAL EFFECT OF HDM ON MIXED LYMPHOCYTE CELL CULTURE (MLC) AND ON L1210 CELLS. AT THE DOSES WHICH INHIBIT (3)H-THYMIDINE INCORPORATION INTO L1210 CELLS BY 50 PERCENT, THE RESPONSE OF THE MLC WAS STIMULATED TWO-FOLD. SINCE HDM IS A HETEROGENEOUS MIXTURE OF DIFFERENT MOLECULAR WEIGHTS, THIS PROPOSAL IS FOR ISOLATION OF THE MOST ACTIVE MOLECULAR WEIGHT FRACTION AND ITS EVALUATION BOTH "IN VITRO" AND "IN VIVO", AGAINST L1210 AND P388 LEUKEMIAS AND ON MIXED LYMPHOCYTE CULTURE. RESOLUTION WILL BE ATTAINED BY SEPHADEX GEL FILTRATION CHROMATOGRAPHY AND THE ACTIVE FRACTION(S) WILL BE IDENTIFIEDIN "IN VITRO" CELL CULTURE ASSAYS. SINCE HDM COULD CAUSE MAST CELL DEGRANULATION, SOME OF THE ANTITUMOR EVALUATION STUDIES WILL BE CARRIED OUT IN CONJUNCTION WITH ANTIHISTAMINE THERAPY, ESSENTIALLY INVOLVING TREATMENT WITH BENZALKONIUN CHLORIDE OR DIPHENHYDRAMINE TYPE DRUGS.

Principal Investigator:

Leonard m. pratt
PRINCIPAL INVESTIGATOR
2065836562

Business Contact:

Small Business Information at Submission:

Immunogenics Corpon
The Arctic Bldg. 700 3rd Ave., Suite 840 Seattle, WA 98104

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No