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THE AIM OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL ANTIBODYCONJUGATES FOR USE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4743
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4743
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IMMUNOMEDICS, INC.
300 The American Road Morris Plains, NJ 07950-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE AIM OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL ANTIBODYCONJUGATES FOR USE IN THE RADIOIMMUNODETECTION OF TUMORS.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE AIM OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL ANTIBODYCONJUGATES FOR USE IN THE RADIOIMMUNODETECTION OF TUMORS. IN RESPONSE TO THE PROBLEMS ASSOCIATED WITH THE ANTIBODY- DTPA-RADIOMETAL IMAGING METHODOLOGIES WITH REGARD TO LIVER DEPOSITION OF THE METAL, A NUMBER OF MORE SPECIFIC CHELATORSWILL BE INVESTIGATED. BASED ON THE CAPABILITY OF THE CHELATORS TO TIGHTLY BIND THE METAL AND BECAUSE OF THEIR GREATER LIPOPHILIC CHARACTER AND LACK OF EXCESS FUNCTIONALITY, ENHANCEMENT OF MEMBRANE TRANSPORT OF THE LIGAND-METAL COMPLEX IS TO BE EXPECTED. THE OVERALL SYNTHETIC STRATEGY WILL ALLOW A LARGE NUMBER OF ALTERNATIVESTO BE CONSIDERED IN THE FUTURE, WHILE THE COMPOUNDS' CLOSE CORRELATION WITH UBIQUITOUS NATURAL PRODUCTS WOULD NOT INDICATE ANY FUTURE CYTOTOXIC PROBLEMS. ANTIBODY CONJUGATION WILL FOLLOW PROTOCOLS ESTABLISHED IN THESE LABORATORIES AND ELSEWHERE.

Principal Investigator:

Gary l griffiths
PRINCIPAL INVESTIGATOR
2014564779

Business Contact:

Small Business Information at Submission:

Immunomedics Inc
5 Bruce Street, Building 5 Newark, NJ 07103

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No