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THE PRODUCTION OF 188 RE-LABELED MONOCLONAL ANTIBODIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
18988
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
18988
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IMMUNOMEDICS, INC.
300 The American Road Morris Plains, NJ 07950-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: THE PRODUCTION OF 188 RE-LABELED MONOCLONAL ANTIBODIES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE AIM OF THIS PROJECT IS TO ULTIMATELY DEVELOP NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER. THE AGENTS ARE BASED ON THE USE OF RADIOLABELED MONOCLONAL ANTIBODY BEARING THE ISOTOPE, RHENIUM-188. THIS ISOTOPE IS A GENERATOR PRODUCED ITEM WHICH COULD BE USED IN ANY NUCLEAR PHARMACY IN A RAPID MANNER TO GIVE INJECTABLE MATERIAL, AND CARRYING A GAMMA EMISSION AS WELL AS A BETA EMISSION CAN BE USED AS A VISUALIZING AGENT ON SPECT. ANTIBODIES WILL BE LABELED WITH THIS ISOTOPE USING DIRECT LABELING TECHNOLOGY AND TESTED FOR EFFICACY IN SUITABLE ANIMAL MODELS. THE MOST EFFECTIVE FORMAT FOR RHENIUM ANTIBODY WILL BE DETERMINED BY THESE STUDIES, PRIOR TO PHASE II WORK ON DOSE ESCALATION AND TOLERABILITY FOLLOWED BY INITIAL CLINICAL STUDIES. DEVELOPMENT WORK ON THE PRODUCT(S) WILL BE CARRIED OUT IN THE SECOND PHASE GIVEN GOOD CLINICAL RESULTS, AND AT THE END OF PHASE II, MULTI-CENTER CLINICAL TRIALS AND A PHASE III IND ARE TO BE EXPECTED. IT IS ENVISAGED THAT THE PRODUCTS FINAL DESIGN WILL BE SIMPLE ENOUGH TO ALLOW ON-SITE ONE-STEP RADIOLABELING A TRAINED NUCLEAR MEDICINE TECHNOLOGISTS, WITH THE MINIMUM OF ANALYTICAL VALIDATION, AND THEN BE READY FOR IMMEDIATE PATIENT USE.

Principal Investigator:

Gary L Griffiths
2014564779

Business Contact:

Small Business Information at Submission:

Immunomedics Inc
300 American Road Morris Plains, NJ 07950

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No