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Carcinoembryonal Antigen Idiotype Vaccine

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
300 The American Road Morris Plains, NJ 07950-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 1993
Title: Carcinoembryonal Antigen Idiotype Vaccine
Agency: HHS
Contract: N/A
Award Amount: $50,000.00


Cancer patients are usually tolerant to the antigens expressed on tumor cells. Triggering an active immune response by the patients to tumor-associated antigens represents one of the most promising prospects in cancer therapy. In this project, we will perform a preclinical study of the anti-idiotype approach to trigger an active immune response against CEA. Certain anti-idiotypic antibodies directed against the variable regions of antibodies specific for a given antigen can mimic (i. e., bear the internal image of) this antigen. In several experimental systems, immunization with anti-idiotypic antibodies elicited specific immunity in lieu of the original antigen. Immunization with anti-idiotype antibodies as surrogate antigens is a promising approach to trigger immunity to tolerized antigens such as tumor antigens. They have already generated baboon polyclonal and rat monoclonal anti-idiotype antibodies that antigenically mimic CEA. In this project, they will assess whether these anti-idiotype antibodies can function as surrogate antigens in hamsters. Hamsters have been chosen since they are the only known non-immunodeficient animal species in which human CEA-producing tumors may grow. Hamsters represent a unique model to test whether active anti-idiotype immunization can protect against tumor growth. This Phase I study will represent the basis for more extensive preclinical and clinical studies in Phase II.

Principal Investigator:

Hans J. Hansen

Business Contact:

Small Business Information at Submission:

Immunomedics, Inc.
300 American Road Morris Plains, NJ 07950

Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No