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Practical RE 186 Labeled Products for Radioimmunotherapy

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
24886 		Program Year/Program:
1994 / SBIR
Agency Tracking Number:
24886 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
IMMUNOMEDICS, INC.
300 The American Road Morris Plains, NJ 07950-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Practical RE 186 Labeled Products for Radioimmunotherapy
Agency: HHS
Contract: 1 R43 CA64032-1,
Award Amount: $81,000.00
 

Abstract:

Our ultimate goal is to develop a readily usable rhenium-186-labeled monoclonal antibodyproduct for radioimmunotherapy of colorectal and other types of cancer. Rhenium-186 (t1/2=90h) hasbeta-emissions at 1.07 meV and 0.93 MeV, and imageable gamma-emission (9% abundance) at 137KeV. The Phase-I research will involve preparation of chelator-linked conjugates of a high-affinityCEA-specific antibody, single-vial formulations of the same with tin, and demonstration of expeditiousand sit-specific labeling with rhenium-186 perrhenate. Biodistributions of these radioimmunoconjugatesin tumor-bearing mice will be determined. We will produce a lyophilized antibody preparation which canbe labeled, in one step, to obtain a radioimmunoconjugate with high immunoreactivity, and an in vivoretention resembling that of iodinated antibody. A product fulfilling these criteria will be easily usablein hospital settings, and commercially viable. Initial labeling experiments will be carried out usingrhenium-188 perrhenate, which is readily available from an in-house tungsten-rhenium generator.Extensive animal preclinical studies, and initial clinical studies will be carried out in an SBIR Phase IIprogram.

Principal Investigator:

Serengulam Govindan
2016058200

Business Contact:

Small Business Information at Submission:

Immunomedics, Inc.
300 American Road Morris Plains, NJ 07950

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No