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TC-99M-F(AB)2 Instant Kits for Radioimmunoscintigraphy

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
22297 		Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22297 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
IMMUNOMEDICS, INC.
300 The American Road Morris Plains, NJ 07950-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: TC-99M-F(AB)2 Instant Kits for Radioimmunoscintigraphy
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

The goal is to develop the optimum clinical agent for radioimmunoscintigraphy. The optimum nuclide is undoubtedly technetium- 99m. Comparing IgG-SH, F(ab')2-SH and Fab'-SH, it is expected that a F(ab')2-SH fragment will have fast enough clearance from circulation to permit earlier imaging than a comparably radiolabeled IgG-SH, while having less renal uptake than a comparably labeled Fab'-SH fragment. Previously, direct labeling of F(ab')2-SH was problematic in that a 50:50 mixture of Tc-99m-F(ab')2 and Tc99m-Fab' would result due to the presence of a small amount of monovalent fragment. We have a novel technique of pre.reducing intact IgG to break non-hinge region disulfide bonds prior to digestion of antibody. The resulting, pure F(ab')2-SH is capable of quantitative incorporation of technetium-99m, in the same manner as IgG-SH and Fab'-SH, are currently labeled to yield quantitatively Tc-99m-F(ab')2. We will extend the technique to different antibodies targeted against different cancers, and ultimately use humanized F(ab')2-SH fragments. In phase l research, we will prove the superiority of Tc99m-F(ab')2 over Tc-99m- Fab' and Tc-99m-IgG as an early time-point radioimmunoimaging agent; if successful, produce clinically usable kits at the conclusion of the Phase II period.

Principal Investigator:

Gary L. Griffiths
2016058200

Business Contact:

Small Business Information at Submission:

Immunomedics, Inc.
300 American Road Morris Plains, NJ 07950

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No