USA flag logo/image

An Official Website of the United States Government

CDR Grafted Antibody for Radioimmunotherapy of Lymphoma

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29202
Program Year/Program:
1996 / SBIR
Agency Tracking Number:
29202
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IMMUNOMEDICS, INC.
300 The American Road Morris Plains, NJ 07950-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1996
Title: CDR Grafted Antibody for Radioimmunotherapy of Lymphoma
Agency: HHS
Contract: 1 R43 CA66348-01,
Award Amount: $750,000.00
 

Abstract:

This Phase I research will test the hypothesis that an optimum, commercially viable radioimmunotherY-90-radiolabeled cdr-grafted LL2 MAb, targeted against radiosensitive Non-Hodgkin's lymphoma. Y-90because of its desirable radiophysical properties, possible use on an out-patient basis and commercicdr-grafted MAb has been selected in order to minimize human anti-mouse antibody response, which coutreatment. Conjugates will be radiolabeled using a bifunctional chelate based on 2-benzyl-DTPA, sincbe performed in 93- 98 percent incorporation yields within l hour. Y-90-labeled cdr-grafted LL2 willradiolabeled murine LL2 and to the corresponding radioiodinated antibodies for stability; in vitro cinternalization and isotope cellular retention studies, and in vivo in animal tumor xenograft modelsPhase I period, the investigators will have either confirmed the suitability of the Y-90- labeled cdradioimmunotherapy or decided that one of the other agents would be preferred, based on the combinedtumor targeting studies. The final goal is a clinically efficacious, commercially useful, radioimmun

Principal Investigator:

Gary Griffiths
20105

Business Contact:

Small Business Information at Submission:

Immunomedics, Inc.
300 American Road Morris Plains, NJ 07950

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No