The objective of the proposed research is to develop an immunologically specific adsorbent for use in extracorporealsystems to remove immunoreactive igm from the serum of patients for primary biliary cirrhosis (pbc). by standard immunologic techniques, antibodies to human igm will be isolated. these… More

Several recent reports suggest that extracorporeal perfusion of tumor bearing plasma over protein a containing substrates can result in objective tumor regression in the host. in the present investigation, purified staphylococcal protein a is isolated, coupled to an inert biocompatible silica… More

We have reported that extracorporeal immunoadsorption to remove circulating immune complexes (cic) and igg results in complete regression of feline lymphosarcoma, clearance of persistant feline leukemia virus infection and histologic changes associated with improvement in kaposi's sarcoma (ks) in… More

A series of fucosylated glycosphingolipids with the ""x'' determinant (gal 1 4fuc 1 3glcnac) have been shown to accumulate in human colonic and liver adenocarcinoma and are virtually absent in normal colonic mucosa and normal liver tissue. however, small quantities of fucolipids with the ""x''… More

Easier to conjugate to antibodies with higher reproducibility.the aim of this research is to isolate and characterize antigens in circulating immune complexes (cic) from patients with acquired immunodeficiency syndrome and kaposi's sarcoma (aids-ks) and to exploit these antigens for development of… More