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IN VITRO TEST SYSTEM FOR DETERMINING AGENT TOXICITY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13760
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13760
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
In Vitro Technologies, Inc.
Empire State Plaza Baltimore, MD 21233
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: IN VITRO TEST SYSTEM FOR DETERMINING AGENT TOXICITY
Agency: HHS
Contract: N/A
Award Amount: $48,735.00
 

Abstract:

THIS PROJECT IS DESIGNED TO ASSESS THE FEASIBILITY OF EMPLOYING A HUMAN KERATINOCYTE CELL CULTURE IN AN IN VITRO TEST SYSTEM CAPABLE OF DETERMINING THE CUTANEOUS TOXICITY OF AN ENVIRONMENTAL CHEMICAL. SPECIFIC PROJECT AIMS INCLUDE THE STUDY OF MACROMOLECULAR CELLULAR EVENTS TO MEASURE THE DEGREE OF VARIABILITY OF PRIMARY EPIDERMAL CULTURES RELATED TO THE USE OF CULTIVATED KERATINOCYTES ISOLATED FROM TISSUE OBTAINED FROM DIFFERENT DONORS AND THE SELECTION OF APPROPRIATE SOLVENTS FOR USE IN THE TOPICAL APPLICATION OF TEST CHEMICALS TO THE SURFACE OF THE EPIDERMAL CULTURE. SPECIFIC ENZYME LEAKAGE FROM DAMAGEDCELLS WILL BE MEASURED BIOCHEMICALLY TO DETERMINE THE SEVERITY OF THE IRRITATION. THIS PROJECT HAS GREAT POTENTIAL TO PROVIDE TOXICOLOGISTS WITH A FAST, ACCURATE, RELIABLE, AND OBJECTIVE ENDPOINT ASSAY WITH WHICH TO SCREEN CHEMICALS FOR POTENTIAL CUTANEOUSTOXICITY.

Principal Investigator:

Frizell L Vaughan
3139952683

Business Contact:

Small Business Information at Submission:

In Vitro Technology Corp
210 E Huron #c Ann Arbor, MI 48104

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No