DESCRIPTION (provided by applicant): Visceral leishmaniasis (VL) is a disease with high mortality in both developed and developing countries. The causative agents are the parasites Leishmania chagasi, donovani and infantum depending on geographic location. In Mediterranean… More

DESCRIPTION (provided by applicant): Visceral leishmaniasis (VL) is a disease with high mortality in both developed and developing countries. The causative agents are the parasites Leishmania chagasi, donovani and infantum depending on geographic location. In Mediterranean… More

DESCRIPTION (provided by applicant): This proposal is to produce a rapid serodiagnostic and accurate confirmatory test for detection of Trypanosoma cruzi infections built on a novel recombinant antigen. This parasite, transmitted via blood transfusion, is prevalent in Latin America, and the… More

DESCRIPTION (provided by applicant): This proposal is to develop a rapid serodiagnostic and accurate confirmatory test for detection of Trypanosoma cruzi infections built on a set of novel recombinant antigens. This parasite is transmitted via blood transfusion, is prevalent in Latin America, and is… More

The proposed immunochromatographic diagnostic test would be a useful rapid diagnostic test for the direct detection of Leishmania parasites responsible for cutaneous leishmaniasis in soldiers exhibiting skin lesions. It would have application in detecting Leishmania parasites directly from needle… More

DESCRIPTION (provided by applicant): The Gram negative bacterium Burkholderia pseudomallei causes human melioidosis, a rapidly progressing and frequently fatal disease if not treated early. It is endemic in areas of NE Thailand, Southeast Asia and northern parts of Australia and is listed as a… More

The rapid test developed here will provide for improved detection of NHP bacterial infections in the field. This in turn will have economic consequences by enabling shrimp farmers to more rapidly respond to and contain infections.

This objective of this study is to develop a robust, field-grade, screening assay for the detection of fever-causing pathogens including Plasmodium sp., Salmonella, Rickettsial sp., Flaviviruses and Leptospira. The test will utilize lateral flow (dipstick) chromatography incorporated into a unique,… More

The proposed immunochromatographic diagnostic test would be a useful rapid diagnostic test for the direct detection of leishmania parasites responsible for cutaneous leishmaniasis in soldiers exhibiting skin lesions.It would have application in detecting leishmania parasites directly from needle… More

The objective of this study is to develop a robust, field-grade, screening assay for the detection of severe diarrheal disease-causing pathogens including E. coli O157, Salmonella spp., Shigella spp., Cryptosporidium spp., Campylobacter spp., Noroviruses, and Rotaviruses. The test will utilize… More

DESCRIPTION (provided by applicant): Antigen detection assay in contrast to conventional serological test, detects disease status and not the host antibody response to the disease etiological agent. It can therefore be used for both diagnosis and disease treatment follow-up purposes. Antigen… More

DESCRIPTION (provided by applicant): Brucellosis is a re-emerging zoonotic disease that affects humans and a variety of farm animals. As well as a threat to public health it has considerable economic importance. The etiologic agent responsible for human infection, Brucella melitensis, is classified… More

The objective of this study is to develop a robust, field grade, screening assay for the detection of both leishmania parasites and/or sand fly fever viruses directly in sand flies. The test will utilize a multi-line lateral flow (dipstick) chromatography incorporated into a cassette that enables… More

The objective of this study is to develop a robust, field-grade, screening assay for the differential diagnosis of infection by Spotted Fevers (e.g. Rocky Mountain Spotted fever, Boutonneuse fever) and Typhus (Epidemic and Endemic forms) causing rickettsial bacteria. Scrub Typhus (Orientia… More

DESCRIPTION (provided by applicant): Dengue is a mosquito-transmitted acute viral disease of man caused by the Dengue virus, a member of the flaviviridae family. It is endemic in many parts of the world, particularly tropical and sub-tropical regions and q uite recently there have been outbreaks in… More

Aquaculture of shrimp is a multi-billion dollar business worldwide. Infection of shrimp grown by aquaculture with the organism leading to Necrotizing HepatoPancreatitis (NHP) is frequently encountered in North, Central and South America and can lead to devastating economic consequences if not… More

Sand flies can cause illnesses such as Leishmaniasis caused by a parasite or sand fly fever due to sand fly fever viruses. The objective of this study is to develop a robust, field grade, screening assay for the detection of both leishmania parasites and/or sand fly fever viruses directly in sand… More

The objective of this study is to develop a robust, economical, field-grade, screening assay for the detection of severe diarrhea-causing pathogens including Salmonella spp., E. coli O157, Shigella spp., Cryptosporidium spp., Campylobacter spp., Noroviruses and Rotaviruses. The test will utilize… More

The objective of this study is to develop a robust, field-grade, screening assay for the differential diagnosis of infection by Spotted Fevers (e.g. Rocky Mountain Spotted fever, Boutonneuse fever) and Typhus (Epidemic and Endemic forms) causing rickettsial bacteria. Scrub Typhus (Orientia… More

The objective of this study is to develop a robust, field grade, screening assay for the detection of RVFV in human blood and sera. The test will utilize a lateral flow (dipstick) chromatography incorporated into a cassette. The proposed immunochromatographic assay would be a very useful screening… More

The objective of this study is to develop a robust, field deployable, and a cost effective rapid screening assay for the detection of Q fever infection caused by Coxiella burnetii using human blood and sera. The test will utilize a lateral flow based immunochromatographic system (dipstick). The… More

Sand fly fever is actually caused by a group of several viruses often termed Sand fly ever viruses (SFFV) and are typically caused by Toscana, Naples and Sicilian viruses. The Toscana virus is confined to Italy and the Mediterranean basin whereas the Naples and Sicilian viruses are more prevalent… More

DESCRIPTION (provided by applicant): This application is to develop a standardized and FDA cleared rapid serodiagnostic and confirmatory test for detection of Trypanosoma cruzi (T. cruzi) infections. T. cruzi is transmitted via blood transfusions, is preva lent in Latin America, and is the causative… More

Chikungunya an alphavirus, and the West Nile and Dengue Flaviviruses are carried by mosquitoes. While all three initially lead to febrile illness the subsequent clinical outcomes are very different and in some cases dual infections can occur. All three viruses have the potential to lead to fatal… More

Sand flies can cause sand fly fever due to Sand Fly Fever Viruses. The objective of this study is to develop a robust, field grade, screening assay for the detection of both Naples and Sicilian Sand Fly Fever Viruses in human serum. The test will utilize a multi-line lateral flow (dipstick)… More

Leptospirosis outbreaks in US military personnel have been documented in past. Due to the high incidence of this infection in military personnel attending the Jungle Warfare School in Panama, trials of doxycycline prophylaxis and therapy were performed on this population by US Army researchers.… More

The objective of this study is to develop a robust, field deployable, and a cost effective rapid screening assay for the detection of Leptospirosis infection caused by Leptospira pathogens using human blood and sera. The test will utilize a lateral flow based immunochromatographic system (dipstick).… More

DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a Gram-negative bacterium that is the causative agent of melioidosis. The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding. Melioidosis is difficult to trea and diagnose due to… More

DESCRIPTION (provided by applicant): The very common patient complaint of abdominal pain suggests the diagnosis of pancreatitis. Pancreatitis, however, can be difficult to diagnose or rule out, as the blood-based tests used, serum amylase and lipase, demonstrate suboptimal sensitivity and… More

Human Babesiosis is primarily caused by Babesia microti an intraerythrocytic parasite with some cases on the US west coast associated with Babesia duncani (WA-1). Typically tick bites are the route of transmission. However, both organisms have been associated with transfusion related infections and… More