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A Point-of-Care Assay for the Detection of Spotted-fever group and Typhus group…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
81552
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
A072-153-0025
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: A Point-of-Care Assay for the Detection of Spotted-fever group and Typhus group Rickettsia.
Agency / Branch: DOD / ARMY
Contract: W81XWH-08-C-0006
Award Amount: $69,992.00
 

Abstract:

The objective of this study is to develop a robust, field-grade, screening assay for the differential diagnosis of infection by Spotted Fevers (e.g. Rocky Mountain Spotted fever, Boutonneuse fever) and Typhus (Epidemic and Endemic forms) causing rickettsial bacteria. Scrub Typhus (Orientia tsutsugamushi) will be used as a reference control and may be incorporated into the final assay. The test will utilize lateral flow (dipstick) chromatography incorporated into a unique, triplex, cassette that enables the simultaneous screening of Spotted Fever, Typhus and Scrub Typhus group organisms. The proposed immunochromatographic assay would be a very useful for point-of-care screening and as differential diagnostic test to assess individuals presenting with symptoms of infection. In this Phase 1 study we shall evaluate the ability of a panel of rickettsia-derived antigens from the families of pathogens listed above to function as the basis of an IgM/IgG serodetection system. We will then construct prototype assays that will be evaluated against samples from individuals with confirmed infections. Further development of the assay would take place in a Phase 2 study.

Principal Investigator:

William J. Morrow
Director of New Technology
2063445821
wjwmorrow@inbios.com

Business Contact:

Estela Raychaudhuri
President
2063445821
inbios@aol.com
Small Business Information at Submission:

INBIOS INTERNATIONAL
562 Ist Ave S, Suite 600 Seattle, WA 98104

EIN/Tax ID: 911791824
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No