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A Multiplexed Point-of-Care Assay for the Detection of Enteric Pathogens that…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
77443
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
A062-158-0254
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2008
Title: A Multiplexed Point-of-Care Assay for the Detection of Enteric Pathogens that Cause Severe Diarrhea in Deployed Soldiers
Agency / Branch: DOD / ARMY
Contract: W81XWH-07-C-0030
Award Amount: $724,941.00
 

Abstract:

The objective of this study is to develop a robust, economical, field-grade, screening assay for the detection of severe diarrhea-causing pathogens including Salmonella spp., E. coli O157, Shigella spp., Cryptosporidium spp., Campylobacter spp., Noroviruses and Rotaviruses. The test will utilize lateral flow (dipstick) chromatography incorporated into a unique, multiplex cassette that will enable the simultaneous screening of multiple analytes. The proposed immunochromatographic assay would be a very useful rapid screening test to assess individuals presenting with diarrhea of likely infectious etiology. In this Phase II study we will continue the preliminary development work started in the Phase I feasibility investigation. Specifically we will: (1) continue to identify produce, evaluate and optimize the target antigens from the above panel of pathogens in lateral flow systems; (2) as necessary, identify complementary target antigens for each disease category for added sensitivity and specificity; (3) design and development sample preparatory and lateral flow platforms for each assay and combine into a multiplex device; and (5) evaluate the clinical sensitivity and specificity of the test using fecal specimens from confirmed infected, or control individuals.

Principal Investigator:

W. J. Morrow
PI
2063445821
wjwmorrow@inbios.com

Business Contact:

Estela Raychaudhuri
President
2063445821
inbios@aol.com
Small Business Information at Submission:

INBIOS INTERNATIONAL
562 Ist Ave S, Suite 600 Seattle, WA 98104

EIN/Tax ID: 911791824
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No