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Combination Treatment of tPA and Apyrase for Stroke

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85939
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
NS060175
Solicitation Year:
N/A
Solicitation Topic Code:
NINDS
Solicitation Number:
N/A
Small Business Information
APT THERAPEUTICS, INC.
4041 Forest Park Avenue SAINT LOUIS, MO -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: Combination Treatment of tPA and Apyrase for Stroke
Agency: HHS
Contract: 2R44NS060175-02A1
Award Amount: $1,107,154.00
 

Abstract:

DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. Using a protein informatics approach, we have successfully engineered a human apyrase which exhibits significantly higher enzymatic activity and platelet inhibition than the wild-type apyrases. Importantly, the optimized apyrase conferred cerebroprotection against experimental stroke while preve nting intracerebral hemorrhage. With the Phase II grant support, we will determine whether apyrase therapy is more effective while having lower bleeding risk than aspirin and a GPIIb/IIIa receptor antagonist, in combination with r-tPA for thrombolysis of s troke occlusion. PUBLIC HEALTH RELEVANCE: We will utilize clinically relevant embolic stroke models in rats to validate whether human apyrase improves efficacy and reduce cerebral hemorrhage associated with thrombolytic treatment of ischemic stroke.

Principal Investigator:

Ridong Chen
3123398455
RCHEN@APT-THERAPEUTICS.COM

Business Contact:

Ridong Chen
rchen@apt-therapeutics.com
Small Business Information at Submission:

APT THERAPEUTICS, INC.
APT THERAPEUTICS, INC. 4041 Forest Park Avenue SAINT LOUIS, MO -

EIN/Tax ID: 143194771
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No