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Development of a niobuim oxide as a potential coating for dental and orthopedic…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93668
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
DE019034
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INDIANA NANOTECH, LLC
351 WEST TENTH STREET INDIANAPOLIS, IN 46202-4119
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Development of a niobuim oxide as a potential coating for dental and orthopedic i
Agency: HHS
Contract: 1R43DE019034-01A1
Award Amount: $102,110.00
 

Abstract:

DESCRIPTION (provided by applicant): The worldwide market for implant-based dental products is forecasted to approach 3.5 billion by 2010, and although only 9% of the global dental market is allocated to dental implants, it is the fastest growing segment at a rate of 15% per year. These projections could imply that although significant improvements in overall oral health are observed globally, there remains significant problems associated with prosthodontic devices, including versatility, longevity, and p erformance. More specifically, some common failures associated with existing implant materials, dental or orthopedic, include aseptic loosening, long healing times, and delamination of bioactive coatings from the implant substrate. Therefore, by bridging t he fields of dentistry, bioengineering, and materials science we propose to develop a unique implant coating that could function in harmony with existing implant substrates to induce rapid biomimetic processes may provide a significant public health benefi t. The long-term goal of this research endeavor is to develop a unique niobium oxide coating that forms strong interfacial bonds with the implant substrate while stimulating rapid osseointegration when implanted in vivo for high load-bearing applications, such as hip and tooth replacements. We hypothesize this nano-inspired niobium oxide coating exhibits incredible bioactivity by virtue of its self-assembled arrangement created through rapid oxidation in an aqueous electrolyte. The resulting oxide is compri sed of micron-sized cones that manifest crystal sites amenable for epitaxial growth of apatite as well as topology that favors cellular attachment and growth. In this Phase 1 research proposal to the NIDCR, we propose to address the following specific aims :1) deposition of niobium metal onto Ti6Al4V substrates followed by optical and mechanical verification measurements, 2) optimizing niobium metal thickness after anodization via scratch tests, and 3) validation of niobium oxide microcone-induced bioactivit y in vivo. PUBLIC HEALTH RELEVANCE: The worldwide market for implant-based dental products is forecasted to approach 3.5 billion by 2010, and although only 9% of the global dental market is allocated to dental implants, it is the fastest growing segment at a rate of 15% per year. These projections could imply that although significant improvements in overall oral health are observed globally, there remains significant problems associated with prosthodontic devices, including versatility, longevity , and performance. The long-term goal of this research endeavor is to develop a unique niobium oxide coating that forms strong interfacial bonds with the implant substrate while stimulating rapid osseointegration when implanted in vivo for high load-bea ring applications, such as hip and tooth replacements.

Principal Investigator:

Robert L. Karlinsey
3172787892
RKARLINS@GMAIL.COM

Business Contact:

Robert L. Karlinsey
rkarlins@gmail.com
Small Business Information at Submission:

INDIANA NANOTECH, LLC
351 WEST TENTH STREET INDIANAPOLIS, IN 46202

EIN/Tax ID: 120580364
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No