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Novel Microdialysis Technology for Neuroscience Research

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66714
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
NS047951
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INFINITE BIOMEDICAL TECHNOLOGIES, LLC
1101 E. 33rd Street, 3rd Floor BALTIMORE, MD 21218-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Novel Microdialysis Technology for Neuroscience Research
Agency: HHS
Contract: 1R43NS047951-01
Award Amount: $177,341.00
 

Abstract:

DESCRIPTION (provided by applicant): Microdialysis is an important research tool which enables detection and quantitative analysis of neurotransmitters. The technique can be particularly useful for research on brain disorders such as epilepsy and stroke. However, the current probes are relatively large and often result in significant injury to the brain tissue. Additionally, these probes require large quantities of dialysate, thus resulting in reduced sensitivity. This proposal addresses the challenges of miniaturization and sensitivity using both Micro Electro Mechanical Systems (MEMS) technology and a novel polymeric valve and a pump design. During Phase I, we will test the feasibility of using an electroactive polymer (polypyrrole) to actuate a novel pinch valve. Additionally, we propose to use polypyrrole to develop an ultra-low-flow peristaltic pump for transport of the dialysate without external instrumentation. Finally, we will couple these designs to a MEMS-based microfluidic channel system, and validate the technology in vitro. If successful, we envision a Phase II which includes the development and packaging of the MEMS microdialysis probe followed by in vivo testing in a rodent model of epilepsy. We believe that this will provide a useful specific device as well as to contribute to the development of versatile new microfluidic technology.

Principal Investigator:

Ananth Natarajan
6262840077
ananth@i-biomed.com

Business Contact:

Jeffrey Wallace
4108898011
JEFF@I-BIOMED.COM
Small Business Information at Submission:

INFINITE BIOMEDICAL TECHNOLOGIES, LLC
INFINITE BIOMEDICAL TECHNOLOGIES, LLC 2850 N CHARLES ST, STE 100 BALTIMORE, MD 21218

EIN/Tax ID: 522337593
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No