Several properties of phosphazene polymers [r(2)pn]x appear ideal for the immunogenic delivery of a wide variety of antigens. first, they readily form covalent linkages with those reactive groups common to polypeptides, carbohydrates,and many small organic molecules. second, at physiologic phthe… More

Immunotoxins combine the activity of a powerful toxin with an antibody capable of delivering the conjugate to a specific target cell. these compounds have proven effectivein the in vitro elimination of a number of cell types, including leukemia cells and the bone marrow cells implicated in graft… More

The goal of the proposed research is to develop an extensivepanel of ricin a chain immunotoxins which are cytotoxic and specific for subsets of human lymphocytes and other cell types of immunological importance such as granulocytes, monocytes, and antigen presenting cells. the specific aim of the… More

Development of an efficacious and cost-effective diagnostic test for neisseria gonorrhoeae infection is the goal of this project. although current diagnostic methods are sensitive and specific, they are time consuming and costly. because of the enormous morbidity of gonococcal infection in the u.s.,… More

The goal of the research is to determine whether a new mutant of pseudomonas aeruginosa eta with impaired cell surface receptor binding activity will allow the construction of immunotoxins with superior cytotoxicity to immunotoxins constructed with ricin a chain. the long term objective of this… More