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Analysis of tracking based phenotypes in CNS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
79848
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
GM077774
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DRVISION TECHNOLOGIES, LLC
15921 NE 8TH ST, STE 200 BELLEVUE, WA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2009
Title: Analysis of tracking based phenotypes in CNS
Agency: HHS
Contract: 2R44GM077774-02
Award Amount: $1,365,115.00
 

Abstract:

DESCRIPTION (provided by applicant): Project Summary The objective of this project is to develop Prototype and Scale kinetic image recognition software to score tracking based phenotypes in a broad range of microscopy based central nervous system (CNS) a pplications. The target software tool can be flexibly taught to score or screen the precise dynamic phenotypes of interest, and scalable, together with the imaging assay platform (e.g. imaging system, reagents, etc.) to provide high throughput scoring. It will provide 1) motion signal decomposition to isolate heterogeneous spatial-temporal patterns; 2) teachable subcellular object detection; 3) teachable subcellular object tracking; 4) comprehensive track characterization; and 5) kinetic data analysis inter faces to support dynamic phenotype discovery and scoring. We propose to expand and commercialize our tracking technologies including teachable tracking state based tracking, motion energy tracking enhancement and track classification. The work product will be incorporated into our flagship product SVCell, and sold through our commercial partners including Nikon Corporation. The hypothesis is that our tracking software can be used for the accurate and robust analysis of a broad range of CNS applications, and scalable for the high throughput scoring of dynamic tracking characteristics with high speed, accuracy and reliability. To test this hypothesis, we set forth the following specific aims: Aim 1: Optimize the teachable tracking module for a broad range of t racking based phenotypes; Aim 2: Optimize and validate the high throughput scoring of tracking based phenotypes; Aim 3: Evaluate the product readiness of the SVCell tracking beta through field tests and scientific collaborations. This project is significan t because technologies are needed which can flexibly screen a variety of tracking based, dynamic phenotypes at high throughput to support practical and effective CNS related scientific programs in basic research (e.g. phenotyping) and applied research (e.g . drug discovery). Analysis of these dynamic phenotypes in time-lapse microscopy movies could provide insights into CNS disease formation and enable earlier and more effective interventions. PUBLIC HEALTH RELEVANCE: Project Narrative Time-lapse microscopy image recognition can make a significant impact on the fight against neurological diseases and mental illness. By quantifying complex, dynamic phenotypes in the movies, it gives scientists a powerful tool with which to discover the basic mechanisms underly ing important CNS functions, and then screen methods that act on them. This could enable earlier and more effective therapeutic interventions.

Principal Investigator:

Shihjong J. Lee
4256535589
JAMESL@DRVTECHNOLOGIES.COM

Business Contact:

Samuel V. Alworth
Small Business Information at Submission:

DRVISION TECHNOLOGIES, LLC
DRVISION TECHNOLOGIES, LLC 15921 NE 8TH ST, STE 200 BELLEVUE, WA -

EIN/Tax ID: 126260011
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No