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Rodent Cell Line Authentication

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93808
Program Year/Program:
2009 / STTR
Agency Tracking Number:
GM086896
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IMPACT BIOLABS, LLC
IMPACT BIOLABS, LLC 4011 Discovery Drive COLUMBIA, MO 65201
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Rodent Cell Line Authentication
Agency: HHS
Contract: 1R41GM086896-01
Award Amount: $99,999.00
 

Abstract:

DESCRIPTION (provided by applicant): The long term goal of this research is to develop an efficient method to authenticate rodent cell lines. Misidentification as well as inter- and intra-species cross contamination of cell lines is widespread and has a su bstantial negative impact on biomedical research. The use of short tandem repeat (STR) analysis has been shown to be an effective means of authenticating human cell lines, STR genetic profiles have been established for a large number of human cell lines, a nd much of this data is publicly accessible in the ATCC STR Profile Database. Equivalent resources do not currently exist for authentication of rodent cell lines. In order to fill this gap, the specific aims of this application are to develop a multiplex m icrosatellite marker-based test to generate unique genetic profiles for mouse and rat cell lines and to build a database of these profiles to use for rodent cell line authentication. By developing these resources, it will be possible to provide a cost-effe ctive and accurate method for rodent cell line authentication for the research community. PUBLIC HEALTH RELEVANCE: The use of cell lines is a cornerstone of basic biomedical research and the ability to ensure the authenticity of the cell lines is critical to ensuring the integrity and validity of the research results that guide scientific advances affecting public health. Establishing a method for generating unique genetic profiles for rodent cell lines provides a quick, sensitive, and accurate means to ver ify the authenticity of those cell lines being used in research laboratories.

Principal Investigator:

Elizabeth C. Bryda
5738825504
BRYDAE@MISSOURI.EDU

Business Contact:

Riley K. Lela
contact@impactbiolabs.com
Small Business Information at Submission:

IMPACT BIOLABS, LLC
IMPACT BIOLABS, LLC 4011 Discovery Drive COLUMBIA, MO 65201

EIN/Tax ID: 120364821
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF MISSOURI
UNIVERSITY OF MISSOURI
UNIVERSITY HALL
COLUMBIA, MO 65211 1508
RI Type: Nonprofit college or university