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CNS targeted delivery of anti-HIV drugs

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
94029
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
MH086351
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IMPEL NEUROPHARMA, INC.
867 SW SHOREMONT AVE NORMANDY PARK, WA 98166-3645
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: CNS targeted delivery of anti-HIV drugs
Agency: HHS
Contract: 1R43MH086351-01
Award Amount: $495,245.00
 

Abstract:

DESCRIPTION (provided by applicant): This program plans to develop a drug delivery system that provides maximum drug exposure and suppress residual human immunodeficiency virus (HIV)* in the brain and tissues of central nervous system (CNS). The advent of highly active antiretroviral combination drug therapies (HAART) has reduced plasma virus concentration to undetectable level and has extended life-expectancy in HIV+ subjects. However, residual virus in the CNS tissues, experiencing limited drug exposure i s related to neuroAIDS disease progression. In collaboration with University of Washington, Impel NeuroPharma has developed a novel technology that will overcome limited CNS drug access thereby allowing a maximum drug exposure and viral suppression. Instea d of depositing drugs to nasal cells (achieved with traditional nasal delivery devices), this technology deposits drugs in olfactory cells and provides direct access to the brain and CNS, thereby improving the efficiency of CNS delivery. The proposed UW co llaboration will allow Impel to further optimize and develop this device for delivery of anti-HIV drugs into the brain and CNS and evaluating it in appropriate animal models. We envisioned that this product will be used to suppress virus in the CNS as an a djunct to the current oral HARRT, which are effective for suppressing HIV in blood. [*Abbreviation list is enclosed at the end of references] PUBLIC HEALTH RELEVANCE: The proposed University of Washington collaborative research will allow Impel NeuroPharma , Inc to further optimize and develop this device for delivery of anti-HIV drugs into the brain and CNS and evaluating it in appropriate preclinical models. We envisioned that this product will be used to suppress virus in the CNS as an adjunct to the curr ent oral HARRT, which are effective for suppressing HIV in blood.

Principal Investigator:

Rodney J. Ho
2065439434
RODNEYHO@U.WASHINGTON.EDU

Business Contact:

Michael P. Hite
Small Business Information at Submission:

IMPEL NEUROPHARMA, INC.
IMPEL NEUROPHARMA, INC. 867 SW SHOREMONT AVE NORMANDY PARK, WA 98166

EIN/Tax ID: 126305823
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No