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SBIR PHASE I - TOPIC 243 "NOVEL AND IMPROVED METHODS TO MEASURE CANCER…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
94178
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
N43CO0800064
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INTEGRATED MOLECULAR SENORS, INC.
1080 W. HARBOR VIEW DR COEURDALENE, ID 83814
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2008
Title: SBIR PHASE I - TOPIC 243 "NOVEL AND IMPROVED METHODS TO MEASURE CANCER EPIGENETIC
Agency: HHS
Contract: N43CO0800064
Award Amount: $148,989.00
 

Abstract:

The proposed work will advance methylation diagnosis through the creation of a nano electronic methylation detection system. Most methods currently used in the detection of CpG methylation at specific sites require a bisulfate treatment, PCR amplification and other conventional bio-molecular assays which are time-consuming and lack accuracy. Recently, nanowire field effect transistor based electronic devices have shown promising results in the detection of DNA molecules with attractive features of being lab el-free and ultra-sensitive. Based on the previous research by the proposing team in the development of nano-transistor biosensor for DNA methylation detection, it is proposed herein to develop integrated electronic devices for analyzing the DNA methylatio n profiles for cancer cells. Proposed research involves three areas: a) generate specific electronic signals to report DNA methylation events in numerous gene promoters simultaneously (PhaseI); b) improve nano-transistor design, fabrication quality and yie ld (Phase I); and c) develop integrated devices of nano-transistors with deep submicron electronics (Phase II). A unique molecular signal transduction system which transforms molecular recognition events into electronic signals will be used for multiple DN A detection. Nano-transistor detectors are coupled to a set of microelectronic devices specifically designed for molecular electronic charge detection.

Principal Investigator:

Wusi Maki
Small Business Information at Submission:

INTEGRATED MOLECULAR SENORS, INC.
1080 W. HARBOR VIEW DR COEURDALENE, ID 83814

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No