SBIR PHASE I - TOPIC 243 "NOVEL AND IMPROVED METHODS TO MEASURE CANCER EPIGENETIC
The proposed work will advance methylation diagnosis through the creation of a nano electronic methylation detection system. Most methods currently used in the detection of CpG methylation at specific sites require a bisulfate treatment, PCR amplification
and other conventional bio-molecular assays which are time-consuming and lack accuracy. Recently, nanowire field effect transistor based electronic devices have shown promising results in the detection of DNA molecules with attractive features of being lab
el-free and ultra-sensitive. Based on the previous research by the proposing team in the development of nano-transistor biosensor for DNA methylation detection, it is proposed herein to develop integrated electronic devices for analyzing the DNA methylatio
n profiles for cancer cells. Proposed research involves three areas: a) generate specific electronic signals to report DNA methylation events in numerous gene promoters simultaneously (PhaseI); b) improve nano-transistor design, fabrication quality and yie
ld (Phase I); and c) develop integrated devices of nano-transistors with deep submicron electronics (Phase II). A unique molecular signal transduction system which transforms molecular recognition events into electronic signals will be used for multiple DN
A detection. Nano-transistor detectors are coupled to a set of microelectronic devices specifically designed for molecular electronic charge detection.
Small Business Information at Submission:
Principal Investigator:Wusi Maki
INTEGRATED MOLECULAR SENORS, INC.
1080 W. HARBOR VIEW DR COEURDALENE, ID 83814
Number of Employees: