DESCRIPTION (provided by applicant): More than 500 different protein kinases have been identified in humans and represent 1.7% of the human genome. Protein kinases function by catalyzing the transfer of the 3-phosphoryl group of ATP to the hydroxyl group o
n a specific protein substrate. The central… More
Award Year / Program / Phase:2011 / SBIR / Phase I
Agency:HHS
Principal Investigator:Reena Zutshi – 520-495-0161
Award Amount:$287,417.00
Abstract:
DESCRIPTION (provided by applicant): Poly(ADP-ribosyl)ation is a post-translational modification that plays a central role in the regulation of cell death and DNA repair. PAR serves as a surrogate marker for poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG), which are… More
Award Year / Program / Phase:2011 / SBIR / Phase II
Agency:HHS
Principal Investigator:Reena Zutshi – 520-495-0161
Award Amount:$1,705,661.00
Abstract:
DESCRIPTION (provided by applicant): Approximately 518 kinases are encoded by the human genome and serve as critical mediators of signal transduction brought about by a phosphorylation event. Many kinases are known to be involved in diabetes, inflammation,cardiovascular diseases, tumor cell… More